ENSMUSG00000028255


Mus musculus

Features
Gene ID: ENSMUSG00000028255
  
Biological name :Clca1
  
Synonyms : Calcium-activated chloride channel regulator 1 / Clca1 / Q9D7Z6
  
Possible biological names infered from orthology : A8K7I4 / chloride channel accessory 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 145003817
Gene end: 145032776
  
Corresponding Affymetrix probe sets: 10502622 (MoGene1.0st)   1416306_at (Mouse Genome 430 2.0 Array)   1459889_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029919
NCBI entrez gene - 23844     See in Manteia.
MGI - MGI:1346342
RefSeq - NM_017474
RefSeq - XM_006501444
RefSeq Peptide - NP_059502
swissprot - Q9D7Z6
Ensembl - ENSMUSG00000028255
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clca1ENSDARG00000016290Danio rerio
 clca1ENSDARG00000100941Danio rerio
 clca5.1ENSDARG00000099606Danio rerio
 si:ch211-116o3.3ENSDARG00000086498Danio rerio
 ENSGALG00000006322Gallus gallus
 CLCA1ENSG00000016490Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clca4a / CLCA4* / Q14CN2* / chloride channel accessory 4*ENSMUSG0000006854754
Clca4b / chloride channel accessory 4B / CLCA4* / Q14CN2* / chloride channel accessory 4*ENSMUSG0000007419554
Q9QX15 / Clca3a1 / Calcium-activated chloride channel regulator 3A-1 ENSMUSG0000005602548
Clca3a2 / chloride channel accessory 3A2ENSMUSG0000002826248
Clca3b / chloride channel accessory 3BENSMUSG0000003703348
Clca2 / Q8BG22 / Calcium-activated chloride channel regulator 2 / Q9UQC9* / chloride channel accessory 2*ENSMUSG0000003696041


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR004727  Calcium-activated chloride channel protein, chordata
 IPR013642  Calcium-activated chloride channel, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006821 chloride transport ISA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IBA
 molecular_functionGO:0005254 chloride channel activity ISA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Ednrbs-36Pub/Ednrbs-36Pub,Tg(Spry2)69Tpo/0
Genetic Background: B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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