ENSMUSG00000036960


Mus musculus

Features
Gene ID: ENSMUSG00000036960
  
Biological name :Clca2
  
Synonyms : Calcium-activated chloride channel regulator 2 / Clca2 / Q8BG22
  
Possible biological names infered from orthology : chloride channel accessory 2 / Q9UQC9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 145070263
Gene end: 145099443
  
Corresponding Affymetrix probe sets: 10502638 (MoGene1.0st)   1438109_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036029
Ensembl peptide - ENSMUSP00000143161
NCBI entrez gene - 229933     See in Manteia.
MGI - MGI:2139758
RefSeq - XM_006501435
RefSeq - NM_178697
RefSeq - XM_006501433
RefSeq - XM_006501434
RefSeq - XM_006501432
RefSeq Peptide - NP_848812
swissprot - Q8BG22
Ensembl - ENSMUSG00000036960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clca1ENSDARG00000016290Danio rerio
 clca1ENSDARG00000100941Danio rerio
 clca5.1ENSDARG00000099606Danio rerio
 si:ch211-116o3.3ENSDARG00000086498Danio rerio
 CLCA2ENSG00000137975Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clca3b / chloride channel accessory 3BENSMUSG0000003703345
Q9QX15 / Clca3a1 / Calcium-activated chloride channel regulator 3A-1 ENSMUSG0000005602544
Clca3a2 / chloride channel accessory 3A2ENSMUSG0000002826244
Clca4a / CLCA4* / Q14CN2* / chloride channel accessory 4*ENSMUSG0000006854740
Clca1 / Q9D7Z6 / Calcium-activated chloride channel regulator 1 / A8K7I4* / chloride channel accessory 1*ENSMUSG0000002825540
Clca4b / chloride channel accessory 4B / CLCA4* / Q14CN2* / chloride channel accessory 4*ENSMUSG0000007419540


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR004727  Calcium-activated chloride channel protein, chordata
 IPR013642  Calcium-activated chloride channel, N-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IBA
 molecular_functionGO:0005254 chloride channel activity IMP
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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