ENSMUSG00000028413


Mus musculus

Features
Gene ID: ENSMUSG00000028413
  
Biological name :B4galt1
  
Synonyms : B4galt1 / Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Processed beta-1,4-galactosyltransferase 1 / P15535
  
Possible biological names infered from orthology : beta-1,4-galactosyltransferase 1 / P15291
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 40804602
Gene end: 40854005
  
Corresponding Affymetrix probe sets: 10512129 (MoGene1.0st)   1418014_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103731
Ensembl peptide - ENSMUSP00000030121
NCBI entrez gene - 14595     See in Manteia.
MGI - MGI:95705
RefSeq - NM_022305
RefSeq Peptide - NP_071641
swissprot - B1AXY5
swissprot - P15535
swissprot - Q3U478
Ensembl - ENSMUSG00000028413
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b4galt1ENSDARG00000002634Danio rerio
 B4GALT1ENSGALG00000002022Gallus gallus
 P15291ENSG00000086062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z2Y2 / B4galt2 / Beta-1,4-galactosyltransferase 2 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetyl...ENSMUSG0000002854149
Q91YY2 / B4galt3 / Beta-1,4-galactosyltransferase 3 N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid bet...ENSMUSG0000005242342
Q9JJ04 / B4galt4 / Beta-1,4-galactosyltransferase 4 N-acetyllactosamine synthase Lactotriaosylceramide beta-1,4-galactosyltransferase / O60513* / beta-1,4-galactosyltransferase 4*ENSMUSG0000002279337
Q9JMK0 / B4galt5 / Beta-1,4-galactosyltransferase 5 / O43286*ENSMUSG0000001792935
Q9WVK5 / B4galt6 / Beta-1,4-galactosyltransferase 6 Glucosylceramide beta-1,4-galactosyltransferase / Q9UBX8* / beta-1,4-galactosyltransferase 6*ENSMUSG0000005612431
Q8R087 / B4galt7 / Beta-1,4-galactosyltransferase 7 Xylosylprotein 4-beta-galactosyltransferase / Q9UBV7* / beta-1,4-galactosyltransferase 7*ENSMUSG0000002150423


Protein motifs (from Interpro)
Interpro ID Name
 IPR003859  Beta-1,4-galactosyltransferase
 IPR027791  Galactosyltransferase, C-terminal
 IPR027995  Galactosyltransferase, N-terminal
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0002526 acute inflammatory response IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005989 lactose biosynthetic process IMP
 biological_processGO:0006012 galactose metabolic process IDA
 biological_processGO:0006486 protein glycosylation IMP
 biological_processGO:0006487 protein N-linked glycosylation IEA
 biological_processGO:0007155 cell adhesion IGI
 biological_processGO:0007339 binding of sperm to zona pellucida IPI
 biological_processGO:0007341 penetration of zona pellucida IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009101 glycoprotein biosynthetic process IMP
 biological_processGO:0009312 oligosaccharide biosynthetic process IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045136 development of secondary sexual characteristics IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051270 regulation of cellular component movement IDA
 biological_processGO:0060046 regulation of acrosome reaction IMP
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IMP
 biological_processGO:0060055 angiogenesis involved in wound healing IMP
 biological_processGO:0060058 positive regulation of apoptotic process involved in mammary gland involution IMP
 cellular_componentGO:0000138 Golgi trans cisterna IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
 molecular_functionGO:0003945 N-acetyllactosamine synthase activity ISO
 molecular_functionGO:0004461 lactose synthase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0008378 galactosyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0035250 UDP-galactosyltransferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043014 alpha-tubulin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding ISO


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida
Keratan sulfate biosynthesis
Lactose synthesis
Neutrophil degranulation
N-Glycan antennae elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001236 abnormal spinous layer morphology "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: B4galt1tm1Yiw/B4galt1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcktm1Ern/Hcktm1Ern
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: B4galt1tm1Yiw/B4galt1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004514 dystocia "slow or difficult delivery of offspring and/or placenta" [MESH:C13.703.420.288]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: B4galt1tm2Shur/B4galt1tm2Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008295 abnormal zona reticularis morphology "any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013337 abnormal adenohypophysis development "aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke s) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia" [MGI:Anna]
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Allelic Composition: B4galt1tm1Shur/B4galt1tm1Shur
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022991 Lalba / P29752 / Alpha-lactalbumin / P00709* / lactalbumin alpha*  / reaction / complex
 ENSMUSG00000008438 Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*  / reaction / complex
 ENSMUSG00000043468 Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*  / complex / reaction
 ENSMUSG00000028413 P15535 / B4galt1 / Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetyl...  / complex
 ENSMUSG00000022039 Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*  / complex / reaction






 

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