ENSMUSG00000028766


Mus musculus

Features
Gene ID: ENSMUSG00000028766
  
Biological name :Alpl
  
Synonyms : Alkaline phosphatase, tissue-nonspecific isozyme / Alpl / P09242
  
Possible biological names infered from orthology : alkaline phosphatase, liver/bone/kidney / P05186
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 137741733
Gene end: 137796384
  
Corresponding Affymetrix probe sets: 10517587 (MoGene1.0st)   1423611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121548
Ensembl peptide - ENSMUSP00000125041
Ensembl peptide - ENSMUSP00000030551
Ensembl peptide - ENSMUSP00000116308
NCBI entrez gene - 11647     See in Manteia.
MGI - MGI:87983
RefSeq - XM_017319924
RefSeq - NM_001287172
RefSeq - NM_007431
RefSeq - XM_006538497
RefSeq - XM_006538498
RefSeq - XM_006538499
RefSeq - XM_006538500
RefSeq Peptide - NP_001274101
RefSeq Peptide - NP_031457
swissprot - E9Q7P8
swissprot - B1AXF6
swissprot - P09242
swissprot - B1AXF5
Ensembl - ENSMUSG00000028766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alplENSDARG00000015546Danio rerio
 ALPLENSGALG00000023542Gallus gallus
 ALPLENSG00000162551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alpi / alkaline phosphatase, intestinal / ALPP* / P10696* / ALPPL2* / P05187* / P09923* / alkaline phosphatase, placental* / alkaline phosphatase, placental like 2*ENSMUSG0000007944056
P24823 / Alppl2 / Alkaline phosphatase, placental-like / ALPI* / ALPP* / P09923* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosp...ENSMUSG0000002624655
Akp3 / ALPP* / ALPI* / P09923* / ALPPL2* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosphatase, placental like 2*ENSMUSG0000003650054


Protein motifs (from Interpro)
Interpro ID Name
 IPR001952  Alkaline phosphatase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR018299  Alkaline phosphatase, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0003006 developmental process involved in reproduction IGI
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071529 cementum mineralization IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0065010 extracellular membrane-bounded organelle IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004035 alkaline phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016462 pyrophosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: A/?,Tyrem12Ove/Tyrem12Ove
Genetic Background: involves: C57BL/6 * FVB

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aspadeaf14/Aspadeaf14
Genetic Background: BALB/c-Aspadeaf14

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Cd2aptm1Shaw/Cd2ap+
Genetic Background: Not Specified

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: AlplHpp/Alpl+
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: AlplHpp/AlplHpp
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: AlplMhdabap020/AlplMhdabap020
Genetic Background: C3HeB/FeJ-AlplMhdabap020/Ieg

Allelic Composition: AlplBAP023/AlplBAP023
Genetic Background: C3HeB/FeJ-AlplBAP023

Allelic Composition: AlplMhdabap26/AlplMhdabap26
Genetic Background: C3HeB/FeJ-AlplMhdabap26

Allelic Composition: AlplMhdabap27/AlplMhdabap27
Genetic Background: C3HeB/FeJ-AlplMhdabap27

Allelic Composition: AlplMhdabap32/AlplMhdabap32
Genetic Background: C3HeB/FeJ-AlplMhdabap32

Allelic Composition: AlplSAP007/AlplSAP007
Genetic Background: C3HeB/FeJ-AlplSAP007

Allelic Composition: AlplALPLD1/?
Genetic Background: involves: C3HeB/FeJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003933 abnormal cementum morphology "defects in the bonelike rigid connective tissue covering the root of a tooth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aspadeaf14/Aspadeaf14
Genetic Background: BALB/c-Aspadeaf14

 MP:0004189 abnormal alveolar process "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aspadeaf14/Aspadeaf14
Genetic Background: BALB/c-Aspadeaf14

Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chtf18tm1.1KhK/Chtf18tm1.2Khk,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dmrt1tm1Zark/Dmrt1tm1.1Zark
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Ehmt2tm2Yshk/Ehmt2tm2.1Yshk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Resttm1.1Yasu/Resttm1.2Yasu,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: C57BL/6

Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Tet3tm1.1Gxu/Tet3tm1.2Gxu
Genetic Background: involves: 129 * C57BL/6J * SJL

 MP:0009246 pale spleen "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Snrpntm2.1Kaj/Snrpn+,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Snrpntm2.1Kaj/Snrpn+,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Snrpntm2.1Kaj/Snrpn+,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0011165 abnormal tooth root development "aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
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Allelic Composition: Aspadeaf14/Aspadeaf14
Genetic Background: BALB/c-Aspadeaf14

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011411 abnormal gonadal ridge morphology "any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [MGI:anna]
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Allelic Composition: Alpltm1(cre)Nagy/Alpl+,Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011585 decreased alkaline phosphatase activity "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011610 abnormal primordial germ cell apoptosis "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]
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Allelic Composition: Resttm1.1Yasu/Resttm1.2Yasu,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0013250 abnormal dental pulp morphology "any structural anomaly of the soft tissue within the pulp cavity located in the center of a tooth, comprised of living connective tissue containing blood vessels, nerves and lymphatics, and a layer of odontoblasts at the periphery, which participate in dentin repair" [ISBN:068340007X, MGI:csmith]
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Allelic Composition: Aspadeaf14/Aspadeaf14
Genetic Background: BALB/c-Aspadeaf14

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0020138 delayed bone mineralization "late onset of the process by which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0030281 thin parietal bone "reduced thickness of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0030451 abnormal dentin mineralization "anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0030452 abnormal cementum mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum" [GO:0071529]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0030453 abnormal odontoblast morphology "any structural anomaly of the skeletogenic cell on the outer surface of the dental pulp that secretes dentin matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell" [CL:0000060, GO:0071895]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0030493 abnormal tooth root morphology "any structural anomaly of the part of a tooth that is implanted in the gum; the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0030497 short tooth root "decreased length of the part of a tooth that is implanted in the gum; the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0030545 abnormal acellular cementum morphology "any structural anomaly of the acellular layer of cementum, a living tissue that does not incorporate cells (cementocytes) into its structure, consisting only of extracellular matrix components and mineral; acellular cementum is the first cementum deposited on the dentin of the forming root, and is predominantly found on the cervical/coronal portion of the tooth root; it anchors the primary collagen fibers of the periodontal ligament, providing a strong attachment between the tooth and surrounding alveolar bone" [http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0030546 abnormal cellular cementum morphology "any structural anomaly of the layer of cementum that contains cementocytes in lacunae; it is most abundant on the apical portion of the tooth root and in the furcation areas of multirooted teeth, and has a role in posteruptive adjustment of tooth position" [http://dental.pitt.edu/periohistology-glossary, http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548]
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Allelic Composition: Alpltm2.1Jlm/Alpl+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028766 Alpl / P09242 / Alkaline phosphatase, tissue-nonspecific isozyme / P05186* / alkaline phosphatase, liver/bone/kidney*  / complex






 

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