ENSMUSG00000036500


Mus musculus

Features
Gene ID: ENSMUSG00000036500
  
Biological name :Akp3
  
Synonyms : Akp3
  
Possible biological names infered from orthology : alkaline phosphatase, intestinal / alkaline phosphatase, placental / alkaline phosphatase, placental like 2 / ALPI / ALPP / ALPPL2 / P05187 / P09923 / P10696
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 87124973
Gene end: 87127912
  
Corresponding Affymetrix probe sets: 10348131 (MoGene1.0st)   1450572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037497
NCBI entrez gene - 11648     See in Manteia.
MGI - MGI:87984
RefSeq - NM_007432
RefSeq Peptide - NP_031458
swissprot - F8VQM0
Ensembl - ENSMUSG00000036500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alp3ENSDARG00000098063Danio rerio
 alpi.1ENSDARG00000015273Danio rerio
 alpi.2ENSDARG00000053774Danio rerio
 ENSGALG00000007814Gallus gallus
 ALPIENSG00000163295Homo sapiens
 ALPPENSG00000163283Homo sapiens
 ALPPL2ENSG00000163286Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alpi / alkaline phosphatase, intestinal / ALPP* / P10696* / ALPPL2* / P05187* / P09923* / alkaline phosphatase, placental* / alkaline phosphatase, placental like 2*ENSMUSG0000007944075
P24823 / Alppl2 / Alkaline phosphatase, placental-like / ALPI* / ALPP* / P09923* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosp...ENSMUSG0000002624669
Alpl / P09242 / Alkaline phosphatase, tissue-nonspecific isozyme / P05186* / alkaline phosphatase, liver/bone/kidney*ENSMUSG0000002876651


Protein motifs (from Interpro)
Interpro ID Name
 IPR001952  Alkaline phosphatase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR018299  Alkaline phosphatase, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006793 phosphorus metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004035 alkaline phosphatase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Post-translational modification: synthesis of GPI-anchored proteins
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026246 P24823 / Alppl2 / Alkaline phosphatase, placental-like / ALPI* / ALPP* / P09923* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosp...  / complex
 ENSMUSG00000079440 Alpi / alkaline phosphatase, intestinal / ALPP* / P10696* / ALPPL2* / P05187* / P09923* / alkaline phosphatase, placental* / alkaline phosphatase, placental like 2*  / complex
 ENSMUSG00000036500 Akp3 / ALPP* / ALPI* / P09923* / ALPPL2* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosphatase, placental like 2*  / complex






 

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