ENSG00000163295


Homo sapiens

Features
Gene ID: ENSG00000163295
  
Biological name :ALPI
  
Synonyms : alkaline phosphatase, intestinal / ALPI / P09923
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 232456123
Gene end: 232460032
  
Corresponding Affymetrix probe sets: 207140_at (Human Genome U133 Plus 2.0 Array)   211618_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295463
Ensembl peptide - ENSP00000413068
NCBI entrez gene - 248     See in Manteia.
OMIM - 171740
RefSeq - NM_001631
RefSeq Peptide - NP_001622
swissprot - A0A024R4A2
swissprot - F8WEQ0
swissprot - P09923
Ensembl - ENSG00000163295
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alp3ENSDARG00000098063Danio rerio
 alpi.1ENSDARG00000015273Danio rerio
 alpi.2ENSDARG00000053774Danio rerio
 ENSGALG00000007814Gallus gallus
 Akp3ENSMUSG00000036500Mus musculus
 AlpiENSMUSG00000079440Mus musculus
 Alppl2ENSMUSG00000026246Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALPPL2 / P10696 / alkaline phosphatase, placental like 2ENSG0000016328687
ALPP / P05187 / alkaline phosphatase, placentalENSG0000016328385
ALPL / P05186 / alkaline phosphatase, liver/bone/kidneyENSG0000016255155


Protein motifs (from Interpro)
Interpro ID Name
 IPR001952  Alkaline phosphatase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR018299  Alkaline phosphatase, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006501 C-terminal protein lipidation TAS
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0007586 digestion TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004035 alkaline phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Post-translational modification: synthesis of GPI-anchored proteins
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163295 ALPI / P09923 / alkaline phosphatase, intestinal  / complex






 

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