ENSMUSG00000026246


Mus musculus

Features
Gene ID: ENSMUSG00000026246
  
Biological name :Alppl2
  
Synonyms : Alkaline phosphatase, placental-like / Alppl2 / P24823
  
Possible biological names infered from orthology : alkaline phosphatase, intestinal / alkaline phosphatase, placental / alkaline phosphatase, placental like 2 / ALPI / ALPP / P05187 / P09923 / P10696
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 87086694
Gene end: 87089928
  
Corresponding Affymetrix probe sets: 10356353 (MoGene1.0st)   1450635_at (Mouse Genome 430 2.0 Array)   1450636_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027455
Ensembl peptide - ENSMUSP00000139887
NCBI entrez gene - 11650     See in Manteia.
MGI - MGI:108009
RefSeq - XM_011247904
RefSeq - NM_007433
RefSeq - XM_006529082
RefSeq Peptide - NP_031459
swissprot - P24823
Ensembl - ENSMUSG00000026246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alp3ENSDARG00000098063Danio rerio
 alpi.1ENSDARG00000015273Danio rerio
 alpi.2ENSDARG00000053774Danio rerio
 ENSGALG00000007814Gallus gallus
 ALPIENSG00000163295Homo sapiens
 ALPPENSG00000163283Homo sapiens
 ALPPL2ENSG00000163286Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alpi / alkaline phosphatase, intestinal / ALPP* / P10696* / ALPPL2* / P05187* / P09923* / alkaline phosphatase, placental* / alkaline phosphatase, placental like 2*ENSMUSG0000007944077
Akp3 / ALPP* / ALPI* / P09923* / ALPPL2* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosphatase, placental like 2*ENSMUSG0000003650073
Alpl / P09242 / Alkaline phosphatase, tissue-nonspecific isozyme / P05186* / alkaline phosphatase, liver/bone/kidney*ENSMUSG0000002876654


Protein motifs (from Interpro)
Interpro ID Name
 IPR001952  Alkaline phosphatase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR018299  Alkaline phosphatase, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004035 alkaline phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Post-translational modification: synthesis of GPI-anchored proteins
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026246 P24823 / Alppl2 / Alkaline phosphatase, placental-like / ALPI* / ALPP* / P09923* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosp...  / complex
 ENSMUSG00000079440 Alpi / alkaline phosphatase, intestinal / ALPP* / P10696* / ALPPL2* / P05187* / P09923* / alkaline phosphatase, placental* / alkaline phosphatase, placental like 2*  / complex
 ENSMUSG00000036500 Akp3 / ALPP* / ALPI* / P09923* / ALPPL2* / P10696* / P05187* / alkaline phosphatase, placental* / alkaline phosphatase, intestinal* / alkaline phosphatase, placental like 2*  / complex






 

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