ENSMUSG00000028885


Mus musculus

Features
Gene ID: ENSMUSG00000028885
  
Biological name :Smpdl3b
  
Synonyms : P58242 / Smpdl3b / sphingomyelin phosphodiesterase, acid-like 3B
  
Possible biological names infered from orthology : Q92485
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132732966
Gene end: 132757252
  
Corresponding Affymetrix probe sets: 10516956 (MoGene1.0st)   1417300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030709
NCBI entrez gene - 100340     See in Manteia.
MGI - MGI:1916022
RefSeq - NM_133888
RefSeq Peptide - NP_598649
swissprot - P58242
swissprot - Q3TLX9
Ensembl - ENSMUSG00000028885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpdl3bENSDARG00000010130Danio rerio
 SMPDL3BENSGALG00000000737Gallus gallus
 Q92485ENSG00000130768Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70158 / Smpdl3a / sphingomyelin phosphodiesterase, acid-like 3A / Q92484*ENSMUSG0000001987236
Smpd1 / Q04519 / sphingomyelin phosphodiesterase 1, acid lysosomal / P17405* / sphingomyelin phosphodiesterase 1*ENSMUSG0000003704926


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR017064  Acid sphingomyelinase-like phosphodiesterase, predicted
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006685 sphingomyelin catabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response TAS
 biological_processGO:0046466 membrane lipid catabolic process IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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