ENSG00000130768


Homo sapiens

Features
Gene ID: ENSG00000130768
  
Biological name :SMPDL3B
  
Synonyms : Q92485 / SMPDL3B / sphingomyelin phosphodiesterase acid like 3B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.3
Gene start: 27934993
Gene end: 27959157
  
Corresponding Affymetrix probe sets: 1554050_at (Human Genome U133 Plus 2.0 Array)   205309_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363001
Ensembl peptide - ENSP00000449057
Ensembl peptide - ENSP00000449450
Ensembl peptide - ENSP00000362995
Ensembl peptide - ENSP00000388092
NCBI entrez gene - 27293     See in Manteia.
OMIM - 617737
RefSeq - XM_011541260
RefSeq - NM_001009568
RefSeq - NM_001304579
RefSeq - NM_014474
RefSeq - XM_011541259
RefSeq Peptide - NP_001009568
RefSeq Peptide - NP_001291508
RefSeq Peptide - NP_055289
swissprot - F8VXS3
swissprot - Q5T0Y8
swissprot - Q92485
swissprot - F8VWW8
Ensembl - ENSG00000130768
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpdl3bENSDARG00000010130Danio rerio
 SMPDL3BENSGALG00000000737Gallus gallus
 P58242ENSMUSG00000028885Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92484 / SMPDL3A / sphingomyelin phosphodiesterase acid like 3AENSG0000017259438
SMPD1 / P17405 / sphingomyelin phosphodiesterase 1ENSG0000016631127


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR017064  Acid sphingomyelinase-like phosphodiesterase, predicted
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006685 sphingomyelin catabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046466 membrane lipid catabolic process ISS
 biological_processGO:0050728 negative regulation of inflammatory response ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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