ENSG00000172594


Homo sapiens

Features
Gene ID: ENSG00000172594
  
Biological name :SMPDL3A
  
Synonyms : Q92484 / SMPDL3A / sphingomyelin phosphodiesterase acid like 3A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q22.31
Gene start: 122789049
Gene end: 122809720
  
Corresponding Affymetrix probe sets: 1562512_at (Human Genome U133 Plus 2.0 Array)   213624_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357425
Ensembl peptide - ENSP00000442152
NCBI entrez gene - 10924     See in Manteia.
OMIM - 610728
RefSeq - XM_017010204
RefSeq - NM_001286138
RefSeq - NM_006714
RefSeq - XM_005266799
RefSeq - XM_005266801
RefSeq - XM_005266802
RefSeq - XM_005266797
RefSeq - XM_005266798
RefSeq Peptide - NP_006705
RefSeq Peptide - NP_001273067
swissprot - Q92484
Ensembl - ENSG00000172594
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpdl3aENSDARG00000053119Danio rerio
 ENSGALG00000030275Gallus gallus
 P70158ENSMUSG00000019872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92485 / SMPDL3B / sphingomyelin phosphodiesterase acid like 3BENSG0000013076838
SMPD1 / P17405 / sphingomyelin phosphodiesterase 1ENSG0000016631127


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR017064  Acid sphingomyelinase-like phosphodiesterase, predicted
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006685 sphingomyelin catabolic process IEA
 biological_processGO:0009143 nucleoside triphosphate catabolic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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