ENSMUSG00000029434


Mus musculus

Features
Gene ID: ENSMUSG00000029434
  
Biological name :Vps33a
  
Synonyms : Q9D2N9 / Vps33a / VPS33A CORVET/HOPS core subunit
  
Possible biological names infered from orthology : AC048338.1 / Q96AX1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 123528659
Gene end: 123573038
  
Corresponding Affymetrix probe sets: 10533644 (MoGene1.0st)   1434816_at (Mouse Genome 430 2.0 Array)   1453742_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142813
Ensembl peptide - ENSMUSP00000031388
NCBI entrez gene - 77573     See in Manteia.
MGI - MGI:1924823
RefSeq - NM_029929
RefSeq - XM_006530503
RefSeq Peptide - NP_084205
swissprot - A0A0G2JEL2
swissprot - Q9D2N9
Ensembl - ENSMUSG00000029434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps33aENSDARG00000101116Danio rerio
 ENSGALG00000004440Gallus gallus
 AC048338.1ENSG00000256861Homo sapiens
 Q96AX1ENSG00000139719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59016 / Vps33b / vacuolar protein sorting 33B / Q9H267* / AC068831.7* / VPS33B, late endosome and lysosome associated*ENSMUSG0000003053433


Protein motifs (from Interpro)
Interpro ID Name
 IPR001619  Sec1-like protein
 IPR027121  Vacuolar protein sorting-associated protein 33
 IPR036045  Sec1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0032400 melanosome localization ISO
 biological_processGO:0032418 lysosome localization ISO
 biological_processGO:0035751 regulation of lysosomal lumen pH ISO
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048070 regulation of developmental pigmentation IMP
 biological_processGO:0097352 autophagosome maturation ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030123 AP-3 adaptor complex ISO
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030897 HOPS complex ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0033263 CORVET complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0071439 clathrin complex ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005100 abnormal choroid pigmentation "anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hrrh/Hrrh
Genetic Background: RHJ/LeJ

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr