ENSMUSG00000029868


Mus musculus

Features
Gene ID: ENSMUSG00000029868
  
Biological name :Trpv6
  
Synonyms : Q91WD2 / transient receptor potential cation channel, subfamily V, member 6 / Trpv6
  
Possible biological names infered from orthology : Q9H1D0
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.1
Gene start: 41620624
Gene end: 41636405
  
Corresponding Affymetrix probe sets: 10544348 (MoGene1.0st)   1419615_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143854
Ensembl peptide - ENSMUSP00000031902
NCBI entrez gene - 64177     See in Manteia.
MGI - MGI:1927259
RefSeq - NM_022413
RefSeq Peptide - NP_071858
swissprot - A0A0J9YMK6
swissprot - Q91WD2
Ensembl - ENSMUSG00000029868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpv6ENSDARG00000014496Danio rerio
 ENSGALG00000014746Gallus gallus
 TRPV6ENSG00000165125Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpv5 / P69744 / Transient receptor potential cation channel subfamily V member 5 / Q9NQA5*ENSMUSG0000003689970
Trpv4 / Q9EPK8 / Transient receptor potential cation channel subfamily V member 4 / Q9HBA0*ENSMUSG0000001415828
Trpv1 / Q704Y3 / Transient receptor potential cation channel subfamily V member 1 / Q8NER1*ENSMUSG0000000595226
Trpv3 / Q8K424 / Transient receptor potential cation channel subfamily V member 3 / Q8NET8*ENSMUSG0000004302925
Trpv2 / Q9WTR1 / Transient receptor potential cation channel subfamily V member 2 / Q9Y5S1*ENSMUSG0000001850724


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR004729  Transient receptor potential channel
 IPR005821  Ion transport domain
 IPR008344  Transient receptor potential cation channel subfamily V member 5/6
 IPR008345  Transient receptor potential channel, vanilloid 6
 IPR020683  Ankyrin repeat-containing domain
 IPR024862  Transient receptor potential cation channel subfamily V
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035898 parathyroid hormone secretion IMP
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport ISO
 biological_processGO:0098703 calcium ion import across plasma membrane ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009325 necrospermia "condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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