ENSMUSG00000005952


Mus musculus

Features
Gene ID: ENSMUSG00000005952
  
Biological name :Trpv1
  
Synonyms : Q704Y3 / Transient receptor potential cation channel subfamily V member 1 / Trpv1
  
Possible biological names infered from orthology : Q8NER1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 73234292
Gene end: 73261242
  
Corresponding Affymetrix probe sets: 10378349 (MoGene1.0st)   1443392_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006106
Ensembl peptide - ENSMUSP00000099585
Ensembl peptide - ENSMUSP00000104110
Ensembl peptide - ENSMUSP00000116400
NCBI entrez gene - 193034     See in Manteia.
MGI - MGI:1341787
RefSeq - NM_001001445
RefSeq Peptide - NP_001001445
swissprot - Q704Y3
swissprot - Z4YJD4
swissprot - Z4YKR8
swissprot - Z4YLZ2
Ensembl - ENSMUSG00000005952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpv1ENSDARG00000059883Danio rerio
 TRPV1ENSGALG00000004649Gallus gallus
 TRPV1ENSG00000196689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpv4 / Q9EPK8 / Transient receptor potential cation channel subfamily V member 4 / Q9HBA0*ENSMUSG0000001415844
Trpv2 / Q9WTR1 / Transient receptor potential cation channel subfamily V member 2 / Q9Y5S1*ENSMUSG0000001850742
Trpv3 / Q8K424 / Transient receptor potential cation channel subfamily V member 3 / Q8NET8*ENSMUSG0000004302937
Trpv6 / Q91WD2 / transient receptor potential cation channel, subfamily V, member 6 / Q9H1D0*ENSMUSG0000002986824
Trpv5 / P69744 / Transient receptor potential cation channel subfamily V member 5 / Q9NQA5*ENSMUSG0000003689922


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR004729  Transient receptor potential channel
 IPR005821  Ion transport domain
 IPR008347  Transient receptor potential channel, vanilloid 1-4
 IPR020683  Ankyrin repeat-containing domain
 IPR024862  Transient receptor potential cation channel subfamily V
 IPR024863  Transient receptor potential cation channel subfamily V member 1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0001660 fever generation IMP
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0002024 diet induced thermogenesis IMP
 biological_processGO:0002790 peptide secretion IMP
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport ISA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010243 response to organonitrogen compound IMP
 biological_processGO:0014047 glutamate secretion IEA
 biological_processGO:0014832 urinary bladder smooth muscle contraction IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0034220 ion transmembrane transport IMP
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0050954 sensory perception of mechanical stimulus IMP
 biological_processGO:0050955 thermoception IEA
 biological_processGO:0050960 detection of temperature stimulus involved in thermoception IDA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0050968 detection of chemical stimulus involved in sensory perception of pain IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060083 smooth muscle contraction involved in micturition IMP
 biological_processGO:0060454 positive regulation of gastric acid secretion IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070588 calcium ion transmembrane transport ISS
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071468 cellular response to acidic pH IEA
 biological_processGO:0071502 cellular response to temperature stimulus IEA
 biological_processGO:0090212 negative regulation of establishment of blood-brain barrier IEA
 biological_processGO:0098703 calcium ion import across plasma membrane IEA
 biological_processGO:1901594 response to capsazepine IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005231 excitatory extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0015278 calcium-release channel activity IEA
 molecular_functionGO:0017081 chloride channel regulator activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0097603 temperature-gated ion channel activity IMP


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001986 taste sensitivity/ preferences 
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001987 alcohol preference 
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0003022 increased coronary flow rate "elevated rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0003821 decreased left ventricle diastolic pressure "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0003823 increased left ventricular developed pressure "increase in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0008860 abnormal hair cycle telogen phase "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009287 decreased abdominal fat pad weight "less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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