ENSMUSG00000014158


Mus musculus

Features
Gene ID: ENSMUSG00000014158
  
Biological name :Trpv4
  
Synonyms : Q9EPK8 / Transient receptor potential cation channel subfamily V member 4 / Trpv4
  
Possible biological names infered from orthology : Q9HBA0
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114622152
Gene end: 114658421
  
Corresponding Affymetrix probe sets: 10532839 (MoGene1.0st)   1417545_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107836
Ensembl peptide - ENSMUSP00000107844
Ensembl peptide - ENSMUSP00000107840
Ensembl peptide - ENSMUSP00000107838
Ensembl peptide - ENSMUSP00000071859
NCBI entrez gene - 63873     See in Manteia.
MGI - MGI:1926945
RefSeq - XM_011248235
RefSeq - NM_022017
RefSeq - XM_006530432
RefSeq Peptide - NP_071300
swissprot - E9Q7L7
swissprot - Q9EPK8
swissprot - D3Z1H6
swissprot - D3Z1H7
Ensembl - ENSMUSG00000014158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpv4ENSDARG00000061941Danio rerio
 TRPV4ENSGALG00000036360Gallus gallus
 TRPV4ENSG00000111199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpv1 / Q704Y3 / Transient receptor potential cation channel subfamily V member 1 / Q8NER1*ENSMUSG0000000595243
Trpv2 / Q9WTR1 / Transient receptor potential cation channel subfamily V member 2 / Q9Y5S1*ENSMUSG0000001850737
Trpv3 / Q8K424 / Transient receptor potential cation channel subfamily V member 3 / Q8NET8*ENSMUSG0000004302935
Trpv6 / Q91WD2 / transient receptor potential cation channel, subfamily V, member 6 / Q9H1D0*ENSMUSG0000002986824
Trpv5 / P69744 / Transient receptor potential cation channel subfamily V member 5 / Q9NQA5*ENSMUSG0000003689923


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR004729  Transient receptor potential channel
 IPR005821  Ion transport domain
 IPR008347  Transient receptor potential channel, vanilloid 1-4
 IPR008348  Transient receptor potential channel, vanilloid 4
 IPR020683  Ankyrin repeat-containing domain
 IPR024862  Transient receptor potential cation channel subfamily V
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002024 diet induced thermogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006970 response to osmotic stress IDA
 biological_processGO:0006971 hypotonic response IEA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0007231 osmosensory signaling pathway IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030103 vasopressin secretion IMP
 biological_processGO:0031117 positive regulation of microtubule depolymerization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0034605 cellular response to heat IMP
 biological_processGO:0042538 hyperosmotic salinity response IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043117 positive regulation of vascular permeability IMP
 biological_processGO:0043622 cortical microtubule organization IEA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046785 microtubule polymerization IEA
 biological_processGO:0047484 regulation of response to osmotic stress IMP
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0050891 multicellular organismal water homeostasis ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060351 cartilage development involved in endochondral bone morphogenesis ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070509 calcium ion import IDA
 biological_processGO:0070588 calcium ion transmembrane transport ISO
 biological_processGO:0071470 cellular response to osmotic stress IMP
 biological_processGO:0071476 cellular hypotonic response IDA
 biological_processGO:0071477 cellular hypotonic salinity response IMP
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0071642 positive regulation of macrophage inflammatory protein 1 alpha production IMP
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production IMP
 biological_processGO:0097497 blood vessel endothelial cell delamination ISO
 biological_processGO:1903444 negative regulation of brown fat cell differentiation IMP
 biological_processGO:1903759 signal transduction involved in regulation of aerobic respiration IMP
 biological_processGO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005034 osmosensor activity IMP
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity ISS
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0015275 stretch-activated, cation-selective, calcium channel activity ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0005203 abnormal trabecular meshwork morphology "structural anomaly in the porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

 MP:0005611 decreased circulating antidiuretic hormone level "less than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0008998 decreased blood osmolality "decrease in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Thtm1Tna/Thtm1Tna
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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