ENSMUSG00000018507


Mus musculus

Features
Gene ID: ENSMUSG00000018507
  
Biological name :Trpv2
  
Synonyms : Q9WTR1 / Transient receptor potential cation channel subfamily V member 2 / Trpv2
  
Possible biological names infered from orthology : Q9Y5S1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 62574486
Gene end: 62600515
  
Corresponding Affymetrix probe sets: 10376868 (MoGene1.0st)   1416935_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018651
Ensembl peptide - ENSMUSP00000099703
NCBI entrez gene - 22368     See in Manteia.
MGI - MGI:1341836
RefSeq - XM_017314501
RefSeq - NM_011706
RefSeq - XM_006533165
RefSeq - XM_011248971
RefSeq Peptide - NP_035836
swissprot - Q9WTR1
Ensembl - ENSMUSG00000018507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpv1ENSDARG00000059883Danio rerio
 TRPV2ENSGALG00000004519Gallus gallus
 TRPV2ENSG00000187688Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpv1 / Q704Y3 / Transient receptor potential cation channel subfamily V member 1 / Q8NER1*ENSMUSG0000000595246
Trpv4 / Q9EPK8 / Transient receptor potential cation channel subfamily V member 4 / Q9HBA0*ENSMUSG0000001415843
Trpv3 / Q8K424 / Transient receptor potential cation channel subfamily V member 3 / Q8NET8*ENSMUSG0000004302938
Trpv6 / Q91WD2 / transient receptor potential cation channel, subfamily V, member 6 / Q9H1D0*ENSMUSG0000002986824
Trpv5 / P69744 / Transient receptor potential cation channel subfamily V member 5 / Q9NQA5*ENSMUSG0000003689923


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR004729  Transient receptor potential channel
 IPR005821  Ion transport domain
 IPR008347  Transient receptor potential channel, vanilloid 1-4
 IPR020683  Ankyrin repeat-containing domain
 IPR024862  Transient receptor potential cation channel subfamily V
 IPR024865  Transient receptor potential channel, vanilloid 2
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0009266 response to temperature stimulus ISO
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090280 positive regulation of calcium ion import IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0032584 growth cone membrane IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity ISO
 molecular_functionGO:0005262 calcium channel activity IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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