ENSMUSG00000030020


Mus musculus

Features
Gene ID: ENSMUSG00000030020
  
Biological name :Prickle2
  
Synonyms : Prickle2 / prickle planar cell polarity protein 2 / Q80Y24
  
Possible biological names infered from orthology : Q7Z3G6
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 92370908
Gene end: 92706155
  
Corresponding Affymetrix probe sets: 10546421 (MoGene1.0st)   1428808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032093
Ensembl peptide - ENSMUSP00000109072
Ensembl peptide - ENSMUSP00000109073
Ensembl peptide - ENSMUSP00000109074
NCBI entrez gene - 243548     See in Manteia.
MGI - MGI:1925144
RefSeq - XM_006506106
RefSeq - NM_001081146
RefSeq - NM_001134459
RefSeq - NM_001134460
RefSeq - NM_001134461
RefSeq Peptide - NP_001074615
RefSeq Peptide - NP_001127931
RefSeq Peptide - NP_001127932
RefSeq Peptide - NP_001127933
swissprot - Q80Y24
swissprot - A7YQ68
Ensembl - ENSMUSG00000030020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prickle2aENSDARG00000020982Danio rerio
 prickle2bENSDARG00000037593Danio rerio
 PRICKLE2ENSGALG00000007332Gallus gallus
 Q7Z3G6ENSG00000163637Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U5C7 / Prickle1 / Prickle-like protein 1 / Q96MT3* / prickle planar cell polarity protein 1*ENSMUSG0000003615846
Q80VL3 / Prickle3 / Prickle planar cell polarity protein 3 / O43900*ENSMUSG0000003114537
Gm4907 / TES* / Q9UGI8* / testin LIM domain protein*ENSMUSG0000006811316
Tes / testis derived transcript / Q9UGI8* / testin LIM domain protein*ENSMUSG0000002955216
Gm4985 / TES* / Q9UGI8* / testin LIM domain protein*ENSMUSG0000009010216
Gm21981 / Q2TBC4* / PRICKLE4* / AL365205.1* / prickle planar cell polarity protein 4*ENSMUSG0000007944415
Prickle4 / prickle planar cell polarity protein 4 / Q2TBC4* / AL365205.1*ENSMUSG0000009654915
Lmcd1 / Q8VEE1 / LIM and cysteine-rich domains 1 / Q9NZU5*ENSMUSG0000005760413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR010442  PET domain
 IPR033723  PET prickle
 IPR033725  LIM1 prickle
 IPR033726  LIM2 prickle
 IPR033727  LIM3 prickle


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IMP
 biological_processGO:0001830 trophectodermal cell fate commitment IMP
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Prickle2tm1Nue/Prickle2tm1Nue
Genetic Background: B6.Cg-Prickle2tm1Nue

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Prickle2tm1Nue/Prickle2tm1Nue
Genetic Background: B6.Cg-Prickle2tm1Nue

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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