Manteia - Molecule gene

ENSMUSG00000036158

Mus musculus

Features

Gene ID:	ENSMUSG00000036158

Biological name :	Prickle1

Synonyms :	Prickle1 / Prickle-like protein 1 / Q3U5C7

Possible biological names infered from orthology :	prickle planar cell polarity protein 1 / Q96MT3

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	E3
Gene start:	93499114
Gene end:	93595891

Corresponding Affymetrix probe sets:	10431738 (MoGene1.0st) 1442172_at (Mouse Genome 430 2.0 Array) 1444759_at (Mouse Genome 430 2.0 Array) 1452249_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000049204 Ensembl peptide - ENSMUSP00000104878 NCBI entrez gene - 106042 See in Manteia. MGI - MGI:1916034 RefSeq - XM_006520266 RefSeq - NM_001033217 RefSeq - XM_006520264 RefSeq - XM_006520265 RefSeq Peptide - NP_001028389 swissprot - Q3U5C7 Ensembl - ENSMUSG00000036158

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
prickle1a	ENSDARG00000040649	Danio rerio
prickle1b	ENSDARG00000045694	Danio rerio
PRICKLE1	ENSGALG00000009556	Gallus gallus
Q96MT3	ENSG00000139174	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q80Y24 / Prickle2 / prickle planar cell polarity protein 2 / Q7Z3G6*	ENSMUSG00000030020	49
Q80VL3 / Prickle3 / Prickle planar cell polarity protein 3 / O43900*	ENSMUSG00000031145	31
Gm21981 / Q2TBC4* / PRICKLE4* / AL365205.1* / prickle planar cell polarity protein 4*	ENSMUSG00000079444	16
Prickle4 / prickle planar cell polarity protein 4 / Q2TBC4* / AL365205.1*	ENSMUSG00000096549	16
Tes / testis derived transcript / Q9UGI8* / testin LIM domain protein*	ENSMUSG00000029552	15
Gm4907 / TES* / Q9UGI8* / testin LIM domain protein*	ENSMUSG00000068113	15
Gm4985 / TES* / Q9UGI8* / testin LIM domain protein*	ENSMUSG00000090102	15
Lmcd1 / Q8VEE1 / LIM and cysteine-rich domains 1 / Q9NZU5*	ENSMUSG00000057604	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR001781	Zinc finger, LIM-type
IPR010442	PET domain
IPR033723	PET prickle
IPR033726	LIM2 prickle
IPR033727	LIM3 prickle

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001843	neural tube closure	ISO
biological_process	GO:0006606	protein import into nucleus	ISO
biological_process	GO:0031398	positive regulation of protein ubiquitination	ISO
biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO
biological_process	GO:0035904	aorta development	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0060976	coronary vasculature development	IMP
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO
biological_process	GO:2000691	negative regulation of cardiac muscle cell myoblast differentiation	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031965	nuclear membrane	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Asymmetric localization of PCP proteins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000383	abnormal hair follicle orientation	"misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.3Asw,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0000433	microcephaly	"an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000447	flattened snout		Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000550	abnormal forelimb morphology	"malformation of the entire anterior extremities" [MGI:tc]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000778	abnormal tract		Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0001650	electrically induced seizures	"high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]	Show Allelic Composition: Prickle2^tm1Nue/Prickle2^tm1Nue Genetic Background: B6.Cg-Prickle2^tm1Nue Allelic Composition: Prickle1^m1Ingm/Prickle1⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Prickle1^m2Ingm/Prickle1⁺ Genetic Background: C57BL/6-Prickle1^m2Ingm
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0001693	failure of primitive streak formation	"inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0001724	abnormal extraembryonic endoderm formation	"malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002233	abnormal nose morphology	"any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002544	brachydactyly	"abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002621	delayed neural tube closure	"delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0002703	abnormal renal tubules	"anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.3Asw,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Prickle1^tm1Nue/Prickle1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: C57BL/6J * CBA * LPT/LeJ
MP:0004077	abnormal striatum morphology	"malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004521	abnormal cochlear hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004524	short cochlear hair cell stereocilia	"reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004756	abnormal proximal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0004759	decreased mitotic index	"decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0006032	abnormal ureteric bud morphology	"anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0008151	increased diameter of long bones	"increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0008727	enlarged right atrium	"increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0008788	abnormal fetal cardiomyocyte morphology	"any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0009760	abnormal mitotic spindle	"an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0009909	bifid tongue	"tongue is divided by a midline cleft" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified Allelic Composition: Prickle1^tm1.3Asw/Prickle1^tm1.3Asw,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Prickle1^m1Ingm/Prickle1⁺ Genetic Background: involves: C57BL/6
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0011255	abnormal anterior visceral endoderm cell migration	"any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0011666	double outlet right ventricle, ventricular defect committed to aorta	"a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0012285	misaligned sternebrae	"abnormal alignment of the sternebrae along the ventral midline" [MGI:anna]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0013179	wavy tail	"undulations or a sinusoidal shape of the tail" [MGI:anna]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
MP:0013895	abnormal eyelid cilium morphology	"any structural anomaly of the hairs that grow at the edge of the upper or lower eyelid; eyelashes protect the eye from debris and are sensitive to touch, thus providing a warning that an object is near the eye (which is then closed reflexively)" [MGI:Anna]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0020301	short tongue	"decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [GOC:NV]	Show Allelic Composition: Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0030049	prominent forehead	"forward prominence of the entire forehead, due to protrusion of the frontal bone; not to be confused with frontal bossing" [HP:0011220]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified
MP:0030475	fused lower incisors	"union of two adjacent incisor teeth in the mandible" [MGI:anna]	Show Allelic Composition: Lyn^m2Anu/Lyn^m2Anu Genetic Background: C57B/6JAnu-Lyn^m2Anu/AnuApb Allelic Composition: Prickle1^tm1Asw/Prickle1^tm1.2Asw Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr