ENSDARG00000040649


Danio rerio

Features
Gene ID: ENSDARG00000040649
  
Biological name :prickle1a
  
Synonyms : prickle1a / prickle homolog 1a
  
Possible biological names infered from orthology : PRICKLE1 / Prickle-like protein 1 / prickle planar cell polarity protein 1 / Q3U5C7 / Q96MT3
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 314608
Gene end: 348784
  
Corresponding Affymetrix probe sets: Dr.24985.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000059513
NCBI entrez gene - 368249     See in Manteia.
swissprot - F1Q6J9
ZFIN ID - ZDB-GENE-030724-5
Ensembl - ENSDARG00000040649
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRICKLE1ENSGALG00000009556Gallus gallus
 Q96MT3ENSG00000139174Homo sapiens
 Q3U5C7ENSMUSG00000036158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prickle1b / prickle homolog 1b / Q96MT3* / Q3U5C7* / PRICKLE1* / Prickle-like protein 1 * / prickle planar cell polarity protein 1*ENSDARG0000004569464
prickle2b / prickle homolog 2b / Q7Z3G6* / Q80Y24* / PRICKLE2* / prickle planar cell polarity protein 2*ENSDARG0000003759345
prickle2a / prickle homolog 2a / Q7Z3G6* / PRICKLE2* / prickle planar cell polarity protein 2*ENSDARG0000002098241
prickle3 / prickle homolog 3 / O43900* / Q80VL3* / prickle planar cell polarity protein 3*ENSDARG0000007399628
tes / testis derived transcript (3 LIM domains) / Gm4985* / Q9UGI8* / Gm4907* / testin LIM domain protein* / testis derived transcript*ENSDARG0000005185716
lmcd1 / LIM and cysteine-rich domains 1 / Q8VEE1* / Q9NZU5*ENSDARG0000000200212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR010442  PET domain
 IPR033723  PET prickle
 IPR033725  LIM1 prickle
 IPR033726  LIM2 prickle
 IPR033727  LIM3 prickle


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IGI
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0035622 intrahepatic bile duct development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IGI
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 cellular_componentGO:0005622 intracellular NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle deformed , abnormal
Kupffers vesicle cilium decreased length , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group shape , abnormal
forerunner cell group increased width , abnormal
forerunner cell group malformed , abnormal
forerunner cell group disorganized , abnormal
Show

 ZFA:0000036 liver and biliary system liver and biliary system bile ductule increased amount , abnormal
liver and biliary system intrahepatic bile duct decreased amount , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate mislocalised posteriorly , abnormal
Show

 ZFA:0000075 spinal cord spinal cord duplicated , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver decreased functionality , abnormal
liver mislocalised , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000135 notochord notochord decreased length , abnormal
notochord increased width , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
somite decreased thickness , abnormal
somite condensed , abnormal
Show

 ZFA:0000208 gall bladder gall bladder left side of whole organism , abnormal
gall bladder mislocalised laterally , abnormal
Show

 ZFA:0000279 segmental plate segmental plate increased width , abnormal
Show

 ZFA:0001064 rhombomere rhombomere condensed , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism anatomical axis curved , abnormal
whole organism decreased length , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001114 head head mesoderm increased width , abnormal
Show

 ZFA:0001115 trunk trunk condensed , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved ventral , abnormal
Show

 ZFA:0001211 presumptive rhombomere 5 presumptive rhombomere 5 increased width , abnormal
Show

 ZFA:0001213 presumptive rhombomere 3 presumptive rhombomere 3 increased width , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas mislocalised , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas mislocalised , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer disorganized , abnormal
retinal inner plexiform layer synapse disorganized , abnormal
Show

 ZFA:0001338 intestine intestine mislocalised , abnormal
Show

 ZFA:0001465 photoreceptor inner segment layer photoreceptor inner segment layer disorganized , abnormal
Show

 ZFA:0005169 intrahepatic bile duct intrahepatic bile duct cell decreased amount , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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