ENSMUSG00000030057


Mus musculus

Features
Gene ID: ENSMUSG00000030057
  
Biological name :Cnbp
  
Synonyms : Cnbp / Mus musculus cellular nucleic acid binding protein (Cnbp), transcript variant 4, mRNA. / P53996
  
Possible biological names infered from orthology : CCHC-type zinc finger nucleic acid binding protein / P62633
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87842615
Gene end: 87851106
  
Corresponding Affymetrix probe sets: 10546079 (MoGene1.0st)   1416244_a_at (Mouse Genome 430 2.0 Array)   1437850_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109247
Ensembl peptide - ENSMUSP00000145227
Ensembl peptide - ENSMUSP00000145274
Ensembl peptide - ENSMUSP00000032138
Ensembl peptide - ENSMUSP00000109249
NCBI entrez gene - 12785     See in Manteia.
MGI - MGI:88431
RefSeq - XM_006505479
RefSeq - NM_001109745
RefSeq - NM_001109746
RefSeq - NM_001347325
RefSeq - NM_001355195
RefSeq - NM_013493
RefSeq Peptide - NP_001103215
RefSeq Peptide - NP_001103216
RefSeq Peptide - NP_001334254
RefSeq Peptide - NP_001342124
RefSeq Peptide - NP_038521
swissprot - P53996
swissprot - Q3U935
swissprot - Q3ULK8
swissprot - Q5QJQ9
swissprot - A0A0N4SVS6
Ensembl - ENSMUSG00000030057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnbpaENSDARG00000045776Danio rerio
 cnbpbENSDARG00000070922Danio rerio
 CNBPENSGALG00000005001Gallus gallus
 CNBPENSG00000169714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zcchc13 / zinc finger, CCHC domain containing 13 / Q8WW36* / zinc finger CCHC-type containing 13*ENSMUSG0000003133072


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0004388 absent prechordal plate "absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0012517 absent diencephalon "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0012683 absent telencephalon "absence of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures" [MGI:anna]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0013185 absent anterior definitive endoderm "absence of the mesendoderm which first migrates from the node and which gives rise to the gut" [MGI:anna]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0013505 decreased embryonic tissue cell apoptosis "decrease in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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