ENSMUSG00000030670


Mus musculus

Features
Gene ID: ENSMUSG00000030670
  
Biological name :Cyp2r1
  
Synonyms : Cyp2r1 / Q6VVW9 / Vitamin D 25-hydroxylase
  
Possible biological names infered from orthology : cytochrome P450 family 2 subfamily R member 1 / Q6VVX0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 114549682
Gene end: 114562972
  
Corresponding Affymetrix probe sets: 10567086 (MoGene1.0st)   1444138_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121924
Ensembl peptide - ENSMUSP00000119605
Ensembl peptide - ENSMUSP00000123556
Ensembl peptide - ENSMUSP00000147544
Ensembl peptide - ENSMUSP00000032908
Ensembl peptide - ENSMUSP00000112818
NCBI entrez gene - 244209     See in Manteia.
MGI - MGI:2449771
RefSeq - XM_006507841
RefSeq - NM_177382
RefSeq - XM_006507838
RefSeq - XM_006507839
RefSeq - XM_006507840
RefSeq Peptide - NP_796356
swissprot - Q32MW1
swissprot - Q6VVW9
swissprot - D6RCU9
swissprot - F6RCB2
swissprot - D3YTX0
swissprot - A0A1B0GRJ1
Ensembl - ENSMUSG00000030670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp2r1ENSDARG00000056587Danio rerio
 CYP2R1ENSGALG00000006050Gallus gallus
 CYP2R1ENSG00000186104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp2u1 / Q9CX98 / Cytochrome P450 2U1 / Q7Z449* / cytochrome P450 family 2 subfamily U member 1*ENSMUSG0000002798341
Cyp2j13 / cytochrome P450, family 2, subfamily j, polypeptide 13 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000002857141
Cyp2j6 / O54750 / Cytochrome P450 2J6 / P51589* / CYP2J2* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000005291441
Cyp2j5 / O54749 / Cytochrome P450 2J5 / P51589* / CYP2J2* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000005252041
Cyp2j11 / cytochrome P450, family 2, subfamily j, polypeptide 11 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000006609740
Cyp2j9 / cytochrome P450, family 2, subfamily j, polypeptide 9 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000001522440
Cyp2j8 / cytochrome P450, family 2, subfamily j, polypeptide 8 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008293240
Cyp2j12 / cytochrome P450, family 2, subfamily j, polypeptide 12 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008122540
Cyp2j7 / cytochrome P450, family 2, subfamily j, polypeptide 7 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008136240
Cyp2d22 / cytochrome P450, family 2, subfamily d, polypeptide 22 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000006174038
Cyp2d26 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)*ENSMUSG0000002244537
P24456 / Cyp2d10 / Cytochrome P450 2D10 / CYP2D7* / CYP2D6* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/p...ENSMUSG0000009480635
Cyp2d34 / cytochrome P450, family 2, subfamily d, polypeptide 34 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000009455935
Cyp2d12 / cytochrome P450, family 2, subfamily d, polypeptide 12 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000009685235
P24457 / Cyp2d11 / Cytochrome P450 2D11 / CYP2D7* / CYP2D6* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/p...ENSMUSG0000006808535
Cyp2w1 / E9Q816 / Cytochrome P450 2W1 / Q8TAV3* / cytochrome P450 family 2 subfamily W member 1*ENSMUSG0000002954134
Cyp2d9 / P11714 / Cytochrome P450 2D9 / CYP2D6* / P10635* / CYP2D7* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)*ENSMUSG0000006808634
Cyp2d40 / cytochrome P450, family 2, subfamily d, polypeptide 40 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000006808326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0010164 response to cesium ion IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0036378 calcitriol biosynthetic process from calciol IEA
 biological_processGO:0042359 vitamin D metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0030343 vitamin D3 25-hydroxylase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
Vitamins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt
Genetic Background: B6.129-Cyp27a1tm1Elt/J

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

Allelic Composition: Cyp2r1tm1(KOMP)Vlcg/Cyp2r1+
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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