ENSMUSG00000031636


Mus musculus

Features
Gene ID: ENSMUSG00000031636
  
Biological name :Pdlim3
  
Synonyms : O70209 / Pdlim3 / PDZ and LIM domain protein 3
  
Possible biological names infered from orthology : PDZ and LIM domain 3 / Q53GG5
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 45885461
Gene end: 45919548
  
Corresponding Affymetrix probe sets: 10571601 (MoGene1.0st)   1443299_at (Mouse Genome 430 2.0 Array)   1449178_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148113
Ensembl peptide - ENSMUSP00000034053
NCBI entrez gene - 53318     See in Manteia.
MGI - MGI:1859274
RefSeq - NM_016798
RefSeq - XM_006509465
RefSeq Peptide - NP_058078
swissprot - A0A1B0GSX6
swissprot - O70209
Ensembl - ENSMUSG00000031636
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdlim3aENSDARG00000011023Danio rerio
 pdlim3bENSDARG00000014248Danio rerio
 PDLIM3ENSGALG00000013414Gallus gallus
 PDLIM3ENSG00000154553Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70400 / Pdlim1 / PDZ and LIM domain protein 1 / O00151* / PDZ and LIM domain 1*ENSMUSG0000005504452
P70271 / Pdlim4 / PDZ and LIM domain protein 4 / P50479* / PDZ and LIM domain 4*ENSMUSG0000002038843
Pdlim2 / Q8R1G6 / PDZ and LIM domain protein 2 / Q96JY6* / PDZ and LIM domain 2*ENSMUSG0000002209032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR006643  Zasp-like motif
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IDA
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015629 actin cytoskeleton IPI
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IPI
 molecular_functionGO:0008307 structural constituent of muscle TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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