ENSMUSG00000055044


Mus musculus

Features
Gene ID: ENSMUSG00000055044
  
Biological name :Pdlim1
  
Synonyms : O70400 / Pdlim1 / PDZ and LIM domain protein 1
  
Possible biological names infered from orthology : O00151 / PDZ and LIM domain 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 40221173
Gene end: 40271842
  
Corresponding Affymetrix probe sets: 10467420 (MoGene1.0st)   10520950 (MoGene1.0st)   1416554_at (Mouse Genome 430 2.0 Array)   1437169_at (Mouse Genome 430 2.0 Array)   1437170_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064545
Ensembl peptide - ENSMUSP00000138383
NCBI entrez gene - 54132     See in Manteia.
MGI - MGI:1860611
RefSeq - NM_016861
RefSeq Peptide - NP_058557
swissprot - O70400
swissprot - S4R1V0
Ensembl - ENSMUSG00000055044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdlim1ENSDARG00000019845Danio rerio
 PDLIM1ENSGALG00000005422Gallus gallus
 O00151ENSG00000107438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70209 / Pdlim3 / PDZ and LIM domain protein 3 / Q53GG5* / PDZ and LIM domain 3*ENSMUSG0000003163650
P70271 / Pdlim4 / PDZ and LIM domain protein 4 / P50479* / PDZ and LIM domain 4*ENSMUSG0000002038844
Pdlim2 / Q8R1G6 / PDZ and LIM domain protein 2 / Q96JY6* / PDZ and LIM domain 2*ENSMUSG0000002209033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR006643  Zasp-like motif
 IPR028537  PDZ and LIM domain protein 1
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2ho-18J/Grid2ho-18J
Genetic Background: B6.Cg-Grid2ho-18J/GrsrJ

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grid2ho-18J/Grid2ho-18J
Genetic Background: B6.Cg-Grid2ho-18J/GrsrJ

Allelic Composition: Pdlim1Gt(IST12013D3)Tigm/Pdlim1Gt(IST12013D3)Tigm
Genetic Background: involves: C57BL/6N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grid2ho-18J/Grid2ho-18J
Genetic Background: B6.Cg-Grid2ho-18J/GrsrJ

Allelic Composition: Pdlim1Gt(IST12013D3)Tigm/Pdlim1Gt(IST12013D3)Tigm
Genetic Background: involves: C57BL/6N

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2ho-18J/Grid2ho-18J
Genetic Background: B6.Cg-Grid2ho-18J/GrsrJ

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2ho-18J/Grid2ho-18J
Genetic Background: B6.Cg-Grid2ho-18J/GrsrJ

Allelic Composition: Pdlim1Gt(IST12013D3)Tigm/Pdlim1Gt(IST12013D3)Tigm
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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