ENSMUSG00000022090


Mus musculus

Features
Gene ID: ENSMUSG00000022090
  
Biological name :Pdlim2
  
Synonyms : Pdlim2 / PDZ and LIM domain protein 2 / Q8R1G6
  
Possible biological names infered from orthology : PDZ and LIM domain 2 / Q96JY6
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70164218
Gene end: 70177681
  
Corresponding Affymetrix probe sets: 10421258 (MoGene1.0st)   1423946_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022681
Ensembl peptide - ENSMUSP00000119222
Ensembl peptide - ENSMUSP00000141050
Ensembl peptide - ENSMUSP00000139820
Ensembl peptide - ENSMUSP00000116200
Ensembl peptide - ENSMUSP00000116694
NCBI entrez gene - 213019     See in Manteia.
MGI - MGI:2384850
RefSeq - XM_006518782
RefSeq - XM_006518781
RefSeq - XM_006518783
RefSeq - NM_001253736
RefSeq - NM_145978
RefSeq - XM_011245006
RefSeq Peptide - NP_666090
RefSeq Peptide - NP_001240665
swissprot - Q8R1G6
swissprot - E9Q996
swissprot - A0A087WPL1
swissprot - F7C957
Ensembl - ENSMUSG00000022090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdlim2ENSDARG00000069956Danio rerio
 PDLIM2ENSG00000120913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70400 / Pdlim1 / PDZ and LIM domain protein 1 / O00151* / PDZ and LIM domain 1*ENSMUSG0000005504431
P70271 / Pdlim4 / PDZ and LIM domain protein 4 / P50479* / PDZ and LIM domain 4*ENSMUSG0000002038830
O70209 / Pdlim3 / PDZ and LIM domain protein 3 / Q53GG5* / PDZ and LIM domain 3*ENSMUSG0000003163629


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR031847  Domain of unknown function DUF4749
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031005 filamin binding IEA
 molecular_functionGO:0032036 myosin heavy chain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051371 muscle alpha-actinin binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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