ENSMUSG00000032580


Mus musculus

Features
Gene ID: ENSMUSG00000032580
  
Biological name :Rbm5
  
Synonyms : Q91YE7 / Rbm5 / RNA-binding protein 5
  
Possible biological names infered from orthology : P52756 / RNA binding motif protein 5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 107740371
Gene end: 107770996
  
Corresponding Affymetrix probe sets: 10596769 (MoGene1.0st)   1438069_a_at (Mouse Genome 430 2.0 Array)   1441319_at (Mouse Genome 430 2.0 Array)   1444971_at (Mouse Genome 430 2.0 Array)   1452186_at (Mouse Genome 430 2.0 Array)   1452187_at (Mouse Genome 430 2.0 Array)   1456262_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142194
Ensembl peptide - ENSMUSP00000141829
Ensembl peptide - ENSMUSP00000142324
Ensembl peptide - ENSMUSP00000035199
Ensembl peptide - ENSMUSP00000138119
Ensembl peptide - ENSMUSP00000138294
Ensembl peptide - ENSMUSP00000138379
Ensembl peptide - ENSMUSP00000138380
Ensembl peptide - ENSMUSP00000138390
Ensembl peptide - ENSMUSP00000138526
Ensembl peptide - ENSMUSP00000138778
NCBI entrez gene - 83486     See in Manteia.
MGI - MGI:1933204
RefSeq - XM_011242921
RefSeq - NM_148930
RefSeq - XM_006511870
RefSeq - XM_006511871
RefSeq - XM_006511872
RefSeq - XM_006511874
RefSeq - XM_006511875
RefSeq - XM_006511876
RefSeq Peptide - NP_683732
swissprot - S4R273
swissprot - S4R2T4
swissprot - A0A0A6YY86
swissprot - A0A0A6YX44
swissprot - Q91YE7
swissprot - S4R184
swissprot - S4R1N4
swissprot - S4R1V5
swissprot - S4R1U7
Ensembl - ENSMUSG00000032580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbm5ENSDARG00000098280Danio rerio
 RBM5ENSGALG00000039288Gallus gallus
 RBM5ENSG00000003756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm10 / Q99KG3 / Mus musculus RNA binding motif protein 10 (Rbm10), transcript variant 4, mRNA. / P98175* / RNA binding motif protein 10*ENSMUSG0000003106055
Rbm6 / RNA binding motif protein 6 / P78332*ENSMUSG0000003258228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000467  G-patch domain
 IPR000504  RNA recognition motif domain
 IPR001876  Zinc finger, RanBP2-type
 IPR013087  Zinc finger C2H2-type
 IPR033094  RNA-binding protein 5
 IPR034991  RNA-binding protein 5, RNA recognition motif 1
 IPR034993  RNA-binding protein 5, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly ISS
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Rbm5sda/Rbm5sda
Genetic Background: involves: C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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