ENSMUSG00000033813


Mus musculus

Features
Gene ID: ENSMUSG00000033813
  
Biological name :Tcea1
  
Synonyms : P10711 / Tcea1 / Transcription elongation factor A protein 1
  
Possible biological names infered from orthology : P23193 / transcription elongation factor A1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A1
Gene start: 4857814
Gene end: 4897909
  
Corresponding Affymetrix probe sets: 10344633 (MoGene1.0st)   10426301 (MoGene1.0st)   1419257_at (Mouse Genome 430 2.0 Array)   1419258_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080266
Ensembl peptide - ENSMUSP00000129157
NCBI entrez gene - 21399     See in Manteia.
MGI - MGI:1196624
RefSeq - NM_001159751
RefSeq - NM_001159750
RefSeq - NM_011541
RefSeq Peptide - NP_001153222
RefSeq Peptide - NP_001153223
RefSeq Peptide - NP_035671
swissprot - Q3UWX7
swissprot - P10711
swissprot - E9PYD5
Ensembl - ENSMUSG00000033813
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcea1ENSDARG00000003531Danio rerio
 TCEA1ENSGALG00000015274Gallus gallus
 TCEA1ENSG00000187735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcea2 / Q9QVN7 / transcription elongation factor A (SII), 2 / Q15560* / transcription elongation factor A2*ENSMUSG0000005954060
Tcea3 / P23881 / Transcription elongation factor A protein 3 / O75764* / transcription elongation factor A3*ENSMUSG0000000160454
Q3US16 / Tceanc / Transcription elongation factor A N-terminal and central domain-containing protein / Q8N8B7* / transcription elongation factor A N-terminal and central domain containing*ENSMUSG0000005122428


Protein motifs (from Interpro)
Interpro ID Name
 IPR001222  Zinc finger, TFIIS-type
 IPR003617  Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
 IPR003618  Transcription elongation factor S-II, central domain
 IPR006289  Transcription elongation factor, TFIIS
 IPR017923  Transcription factor IIS, N-terminal
 IPR035100  Transcription elongation factor, IIS-type
 IPR035441  TFIIS/LEDGF domain superfamily
 IPR036575  Transcription elongation factor S-II, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1901919 positive regulation of exoribonuclease activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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