ENSMUSG00000034101


Mus musculus

Features
Gene ID: ENSMUSG00000034101
  
Biological name :Ctnnd1
  
Synonyms : Ctnnd1 / Mus musculus catenin (cadherin associated protein), delta 1 (Ctnnd1), transcript variant 7, mRNA. / P30999
  
Possible biological names infered from orthology : catenin delta 1 / O60716
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84600071
Gene end: 84650765
  
Corresponding Affymetrix probe sets: 10484402 (MoGene1.0st)   1422450_at (Mouse Genome 430 2.0 Array)   1437448_s_at (Mouse Genome 430 2.0 Array)   1445830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107307
Ensembl peptide - ENSMUSP00000107327
Ensembl peptide - ENSMUSP00000107326
Ensembl peptide - ENSMUSP00000107325
Ensembl peptide - ENSMUSP00000107324
Ensembl peptide - ENSMUSP00000107323
Ensembl peptide - ENSMUSP00000107322
Ensembl peptide - ENSMUSP00000107321
Ensembl peptide - ENSMUSP00000107320
Ensembl peptide - ENSMUSP00000107319
Ensembl peptide - ENSMUSP00000107318
Ensembl peptide - ENSMUSP00000107317
Ensembl peptide - ENSMUSP00000107316
Ensembl peptide - ENSMUSP00000107315
Ensembl peptide - ENSMUSP00000107314
Ensembl peptide - ENSMUSP00000107313
Ensembl peptide - ENSMUSP00000042543
Ensembl peptide - ENSMUSP00000064518
Ensembl peptide - ENSMUSP00000065252
Ensembl peptide - ENSMUSP00000097524
Ensembl peptide - ENSMUSP00000107299
Ensembl peptide - ENSMUSP00000107304
Ensembl peptide - ENSMUSP00000107305
Ensembl peptide - ENSMUSP00000107306
NCBI entrez gene - 12388     See in Manteia.
MGI - MGI:105100
RefSeq - XM_017315206
RefSeq - XM_017315201
RefSeq - XM_017315179
RefSeq - XM_006498639
RefSeq - XM_006498638
RefSeq - XM_006498626
RefSeq - XM_006498636
RefSeq - XM_006498625
RefSeq - XM_006498635
RefSeq - XM_006498634
RefSeq - XM_006498633
RefSeq - XM_006498632
RefSeq - XM_006498631
RefSeq - XM_006498630
RefSeq - XM_006498628
RefSeq - NM_001085448
RefSeq - NM_001085449
RefSeq - NM_001085450
RefSeq - NM_001085453
RefSeq - NM_001355065
RefSeq - NM_001355066
RefSeq - NM_001355067
RefSeq - NM_007615
RefSeq - XM_017315208
RefSeq - XM_017315210
RefSeq Peptide - NP_001341996
RefSeq Peptide - NP_001078917
RefSeq Peptide - NP_001078918
RefSeq Peptide - NP_001078919
RefSeq Peptide - NP_001078922
RefSeq Peptide - NP_001341993
RefSeq Peptide - NP_001341994
RefSeq Peptide - NP_001341995
RefSeq Peptide - NP_031641
swissprot - P30999
swissprot - E9Q986
swissprot - G3X9V2
swissprot - D3Z2H2
swissprot - D3Z2H7
swissprot - D3Z7H6
swissprot - E9Q8Z4
swissprot - E9Q8Z5
swissprot - E9Q8Z6
swissprot - E9Q8Z8
swissprot - E9Q8Z9
swissprot - E9Q901
swissprot - E9Q903
swissprot - E9Q904
swissprot - E9Q905
swissprot - E9Q906
swissprot - E9Q907
Ensembl - ENSMUSG00000034101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctnnd1ENSDARG00000078233Danio rerio
 CTNND1ENSGALG00000007330Gallus gallus
 CTNND1ENSG00000198561Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*ENSMUSG00000101645100
Arvcf / P98203 / Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog / O00192* / ARVCF, delta catenin family member*ENSMUSG0000000032548
Ctnnd2 / catenin delta-2 isoform 2 / Q9UQB3* / catenin delta 2*ENSMUSG0000002224036
Pkp4 / Q68FH0 / plakophilin 4 / Q99569*ENSMUSG0000002699134
Pkp2 / plakophilin 2 / Q99959*ENSMUSG0000004195721
Pkp3 / Q9QY23 / Plakophilin-3 / Q9Y446*ENSMUSG0000005406520
Pkp1 / P97350 / Plakophilin-1 / Q13835*ENSMUSG0000002641319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028435  Plakophilin/Delta catenin
 IPR028439  Catenin delta-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001738 morphogenesis of a polarized epithelium IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007435 salivary gland morphogenesis IMP
 biological_processGO:0010954 positive regulation of protein processing IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0060690 epithelial cell differentiation involved in salivary gland development IMP
 biological_processGO:0072102 glomerulus morphogenesis IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016600 flotillin complex IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030496 midbody ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
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Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ctnnd1tm1Abre/Ctnnd1tm1Abre
Genetic Background: involves: 129S6/SvEvTac

 MP:0003792 abnormal major salivary gland morphology "any structural malformations of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0004035 abnormal sublingual gland morphology "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnd1tm1Abre/Ctnnd1tm1Abre
Genetic Background: involves: 129S6/SvEvTac

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009051 dilated distal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Ctnnd1tm1Abre/Ctnnd1tm1Abre
Genetic Background: involves: 129S6/SvEvTac

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhohtm1Brak/Rhohtm1Brak,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013300 abnormal submandibular gland physiology "any functional anomaly of either of the large major salivary glands situated beneath the mandible" [MGI:Anna]
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0013540 increased submandibular gland apoptosis "increase in the number of cells of the submandibular gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Bhlha15tm2(Kras)Skz/Bhlha15+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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