ENSMUSG00000026991


Mus musculus

Features
Gene ID: ENSMUSG00000026991
  
Biological name :Pkp4
  
Synonyms : Pkp4 / plakophilin 4 / Q68FH0
  
Possible biological names infered from orthology : Q99569
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.1
Gene start: 59160850
Gene end: 59355208
  
Corresponding Affymetrix probe sets: 10472212 (MoGene1.0st)   1438677_at (Mouse Genome 430 2.0 Array)   1452209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138895
Ensembl peptide - ENSMUSP00000129836
Ensembl peptide - ENSMUSP00000139141
Ensembl peptide - ENSMUSP00000139161
Ensembl peptide - ENSMUSP00000042249
Ensembl peptide - ENSMUSP00000099815
Ensembl peptide - ENSMUSP00000108196
Ensembl peptide - ENSMUSP00000122152
NCBI entrez gene - 227937     See in Manteia.
MGI - MGI:109281
RefSeq - XM_017317554
RefSeq - XM_017317535
RefSeq - XM_017317541
RefSeq - XM_017317543
RefSeq - XM_017317544
RefSeq - XM_017317546
RefSeq - XM_017317547
RefSeq - XM_017317549
RefSeq - XM_017317552
RefSeq - NM_026361
RefSeq - NM_175464
RefSeq - XM_006499171
RefSeq - XM_006499172
RefSeq - XM_006499173
RefSeq - XM_006499175
RefSeq - XM_006499176
RefSeq - XM_006499177
RefSeq - XM_006499179
RefSeq - XM_006499180
RefSeq - XM_017317519
RefSeq - XM_017317524
RefSeq - XM_017317531
RefSeq Peptide - NP_080637
RefSeq Peptide - NP_780673
swissprot - V9GXG7
swissprot - A2AS44
swissprot - Q68FH0
swissprot - A2AS47
swissprot - V9GWY7
swissprot - A2AS45
Ensembl - ENSMUSG00000026991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkp4ENSDARG00000045331Danio rerio
 PKP4ENSGALG00000012561Gallus gallus
 PKP4ENSG00000144283Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctnnd2 / catenin delta-2 isoform 2 / Q9UQB3* / catenin delta 2*ENSMUSG0000002224051
Arvcf / P98203 / Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog / O00192* / ARVCF, delta catenin family member*ENSMUSG0000000032529
P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*ENSMUSG0000010164527
Ctnnd1 / P30999 / Mus musculus catenin (cadherin associated protein), delta 1 (Ctnnd1), transcript variant 7, mRNA. / O60716* / catenin delta 1*ENSMUSG0000003410127
Pkp3 / Q9QY23 / Plakophilin-3 / Q9Y446*ENSMUSG0000005406517
Pkp2 / plakophilin 2 / Q99959*ENSMUSG0000004195717
Pkp1 / P97350 / Plakophilin-1 / Q13835*ENSMUSG0000002641316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR028435  Plakophilin/Delta catenin
 IPR028443  Plakophilin-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030057 desmosome ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0044291 cell-cell contact zone ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0051233 spindle midzone ISO
 cellular_componentGO:0072686 mitotic spindle ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0003795 abnormal bone structure 
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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