ENSMUSG00000034297


Mus musculus

Features
Gene ID: ENSMUSG00000034297
  
Biological name :Med13
  
Synonyms : Med13 / Mediator of RNA polymerase II transcription subunit 13 / Q5SWW4
  
Possible biological names infered from orthology : mediator complex subunit 13 / Q9UHV7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 86267033
Gene end: 86357602
  
Corresponding Affymetrix probe sets: 10389451 (MoGene1.0st)   1436904_at (Mouse Genome 430 2.0 Array)   1438725_at (Mouse Genome 430 2.0 Array)   1444068_at (Mouse Genome 430 2.0 Array)   1453160_at (Mouse Genome 430 2.0 Array)   1453161_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044268
NCBI entrez gene - 327987     See in Manteia.
MGI - MGI:3029632
RefSeq - NM_001080931
RefSeq Peptide - NP_001074400
swissprot - Q5SWW4
Ensembl - ENSMUSG00000034297
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med13aENSDARG00000053884Danio rerio
 med13bENSDARG00000003910Danio rerio
 MED13ENSGALG00000005230Gallus gallus
 MED13ENSG00000108510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Med13l / mediator of RNA polymerase II transcription subunit 13-like isoform 1 / Q71F56* / mediator complex subunit 13 like*ENSMUSG0000001807653


Protein motifs (from Interpro)
Interpro ID Name
 IPR009401  Mediator complex, subunit Med13
 IPR021643  Mediator complex, subunit Med13, N-terminal, metazoa/fungi


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0042632 cholesterol homeostasis IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070328 triglyceride homeostasis IDA
 biological_processGO:1904168 negative regulation of thyroid hormone receptor activity IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex ISO
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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