ENSMUSG00000034610


Mus musculus

Features
Gene ID: ENSMUSG00000034610
  
Biological name :Zcchc11
  
Synonyms : B2RX14 / Zcchc11 / zinc finger, CCHC domain containing 11
  
Possible biological names infered from orthology : Q5TAX3 / zinc finger CCHC-type containing 11
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 108459426
Gene end: 108559421
  
Corresponding Affymetrix probe sets: 10506786 (MoGene1.0st)   1437395_at (Mouse Genome 430 2.0 Array)   1439631_at (Mouse Genome 430 2.0 Array)   1441359_at (Mouse Genome 430 2.0 Array)   1441545_at (Mouse Genome 430 2.0 Array)   1456668_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044836
Ensembl peptide - ENSMUSP00000120172
Ensembl peptide - ENSMUSP00000116253
Ensembl peptide - ENSMUSP00000102284
Ensembl peptide - ENSMUSP00000095538
NCBI entrez gene - 230594     See in Manteia.
MGI - MGI:2445126
RefSeq - XM_017320141
RefSeq - XM_006502983
RefSeq - XM_006502984
RefSeq - XM_017320137
RefSeq - XM_017320138
RefSeq - XM_017320139
RefSeq - XM_017320140
RefSeq - NM_175472
RefSeq - XM_006502978
RefSeq - XM_006502980
RefSeq Peptide - NP_780681
swissprot - A2A9H0
swissprot - A2A8R7
swissprot - A2A8R1
swissprot - A0A0A0MQJ6
swissprot - B2RX14
Ensembl - ENSMUSG00000034610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01065131.1ENSDARG00000101404Danio rerio
 zcchc11ENSDARG00000070271Danio rerio
 ZCCHC11ENSGALG00000010629Gallus gallus
 Q5TAX3ENSG00000134744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zcchc6 / zinc finger, CCHC domain containing 6 / Q5VYS8* / zinc finger CCHC-type containing 6*ENSMUSG0000003524836
Papd4 / Q91YI6 / PAP associated domain containing 4 / Q6PIY7* / poly(A) RNA polymerase D4, non-canonical*ENSMUSG000000421679
Tut1 / Q8R3F9 / terminal uridylyl transferase 1, U6 snRNA-specific / Q9H6E5* / AP002990.1*ENSMUSG000000716458
Mtpap / Q9D0D3 / Poly(A) RNA polymerase, mitochondrial / Q9NVV4* / mitochondrial poly(A) polymerase*ENSMUSG000000242346


Protein motifs (from Interpro)
Interpro ID Name
 IPR001878  Zinc finger, CCHC-type
 IPR002058  PAP/25A-associated
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0010586 miRNA metabolic process IMP
 biological_processGO:0010587 miRNA catabolic process ISO
 biological_processGO:0019827 stem cell population maintenance ISS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing ISO
 biological_processGO:0031123 RNA 3"-end processing IDA
 biological_processGO:0031664 regulation of lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050265 RNA uridylyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: L1camtm4.1Vlem/Y
Genetic Background: either: 129S4.129S2-L1camtm4.1Vlem or B6.129S4-L1camtm4.1Vlem

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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