ENSMUSG00000036180


Mus musculus

Features
Gene ID: ENSMUSG00000036180
  
Biological name :Gatad2a
  
Synonyms : Gatad2a / Q8CHY6 / Transcriptional repressor p66 alpha
  
Possible biological names infered from orthology : GATA zinc finger domain containing 2A / Q86YP4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 69907076
Gene end: 69996384
  
Corresponding Affymetrix probe sets: 10579125 (MoGene1.0st)   1423992_at (Mouse Genome 430 2.0 Array)   1445239_at (Mouse Genome 430 2.0 Array)   1451197_s_at (Mouse Genome 430 2.0 Array)   1451198_at (Mouse Genome 430 2.0 Array)   1455505_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137386
Ensembl peptide - ENSMUSP00000112164
Ensembl peptide - ENSMUSP00000148474
Ensembl peptide - ENSMUSP00000148637
Ensembl peptide - ENSMUSP00000148579
Ensembl peptide - ENSMUSP00000070229
NCBI entrez gene - 234366     See in Manteia.
MGI - MGI:2384585
RefSeq - XM_017312722
RefSeq - XM_017312714
RefSeq - XM_017312715
RefSeq - XM_017312716
RefSeq - XM_017312717
RefSeq - XM_017312718
RefSeq - XM_017312719
RefSeq - XM_017312720
RefSeq - XM_017312721
RefSeq - NM_001113346
RefSeq - NM_001286450
RefSeq - NM_145596
RefSeq - XM_006509636
RefSeq - XM_006509638
RefSeq - XM_011242295
RefSeq Peptide - NP_663571
RefSeq Peptide - NP_001106817
RefSeq Peptide - NP_001273379
swissprot - E9QMN5
swissprot - A0A1D5RM07
swissprot - Q8CHY6
swissprot - A0A1I7Q4G8
swissprot - A0A1D5RM58
Ensembl - ENSMUSG00000036180
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gatad2abENSDARG00000006192Danio rerio
 GATAD2AENSGALG00000042900Gallus gallus
 Q86YP4ENSG00000167491Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHR5 / Gatad2b / Transcriptional repressor p66-beta / Q8WXI9* / GATA zinc finger domain containing 2B*ENSMUSG0000004239039


Protein motifs (from Interpro)
Interpro ID Name
 IPR013088  Zinc finger, NHR/GATA-type
 IPR032346  Transcriptional repressor p66, coiled-coil MBD2-interaction domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001842 neural fold formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0012501 programmed cell death IMP
 biological_processGO:0021506 anterior neuropore closure IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0016581 NuRD complex ISO
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030674 protein binding, bridging ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

 MP:0011256 abnormal neural fold morphology "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
Show

Allelic Composition: Lgr4tm1.1Knis/Lgr4tm1.1Knis,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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