ENSMUSG00000036469


Mus musculus

Features
Gene ID: ENSMUSG00000036469
  
Biological name :March1
  
Synonyms : E3 ubiquitin-protein ligase MARCH1 / March1 / Q6NZQ8
  
Possible biological names infered from orthology : membrane associated ring-CH-type finger 1 / Q8TCQ1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.1
Gene start: 65617900
Gene end: 66471637
  
Corresponding Affymetrix probe sets: 10572050 (MoGene1.0st)   1431367_at (Mouse Genome 430 2.0 Array)   1434955_at (Mouse Genome 430 2.0 Array)   1440209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136545
Ensembl peptide - ENSMUSP00000105887
Ensembl peptide - ENSMUSP00000105888
Ensembl peptide - ENSMUSP00000044070
Ensembl peptide - ENSMUSP00000072302
Ensembl peptide - ENSMUSP00000096305
Ensembl peptide - ENSMUSP00000105882
Ensembl peptide - ENSMUSP00000105884
Ensembl peptide - ENSMUSP00000105885
NCBI entrez gene - 72925     See in Manteia.
MGI - MGI:1920175
RefSeq - XM_017312979
RefSeq - NM_001166372
RefSeq - NM_001166375
RefSeq - NM_001293784
RefSeq - NM_175188
RefSeq - XM_006509758
RefSeq - XM_011242329
RefSeq - XM_017312977
RefSeq - XM_017312978
RefSeq Peptide - NP_001159844
RefSeq Peptide - NP_001159847
RefSeq Peptide - NP_001280713
RefSeq Peptide - NP_780397
swissprot - Q6NZQ8
swissprot - D3YVY0
Ensembl - ENSMUSG00000036469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX470214.1ENSDARG00000110724Danio rerio
 march1ENSDARG00000037487Danio rerio
 MARCH1ENSGALG00000009520Gallus gallus
 MARCH1ENSG00000145416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
March8 / Q9DBD2 / E3 ubiquitin-protein ligase MARCH8 / Q5T0T0* / membrane associated ring-CH-type finger 8*ENSMUSG0000002570265
March2 / Q99M02 / E3 ubiquitin-protein ligase MARCH2 / Q9P0N8* / membrane associated ring-CH-type finger 2*ENSMUSG0000007955723
March9 / Q3TZ87 / E3 ubiquitin-protein ligase MARCH9 / Q86YJ5* / membrane associated ring-CH-type finger 9*ENSMUSG0000004050221
March4 / Q80TE3 / E3 ubiquitin-protein ligase MARCH4 / Q9P2E8* / membrane associated ring-CH-type finger 4*ENSMUSG0000003937220
March3 / Q8BRX9 / E3 ubiquitin-protein ligase MARCH3 / Q86UD3* / membrane associated ring-CH-type finger 3*ENSMUSG0000003265619
Q8CBH7 / March11 / E3 ubiquitin-protein ligase MARCH11 / A6NNE9* / membrane associated ring-CH-type finger 11*ENSMUSG0000002226918


Protein motifs (from Interpro)
Interpro ID Name
 IPR011016  Zinc finger, RING-CH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR033275  E3 ubiquitin-protein ligase MARCH-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002495 antigen processing and presentation of peptide antigen via MHC class II IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031902 late endosome membrane ISO
 cellular_componentGO:0032588 trans-Golgi network membrane IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042287 MHC protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd83tm1.1Lnjt/Cd83tm1.1Lnjt,March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5se Myo6sv
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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