ENSMUSG00000037820


Mus musculus

Features
Gene ID: ENSMUSG00000037820
  
Biological name :Tgm2
  
Synonyms : P21981 / Protein-glutamine gamma-glutamyltransferase 2 / Tgm2
  
Possible biological names infered from orthology : P21980 / transglutaminase 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 158116402
Gene end: 158146436
  
Corresponding Affymetrix probe sets: 10489204 (MoGene1.0st)   1417500_a_at (Mouse Genome 430 2.0 Array)   1426004_a_at (Mouse Genome 430 2.0 Array)   1433428_x_at (Mouse Genome 430 2.0 Array)   1437277_x_at (Mouse Genome 430 2.0 Array)   1438942_x_at (Mouse Genome 430 2.0 Array)   1455900_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099411
Ensembl peptide - ENSMUSP00000133662
NCBI entrez gene - 21817     See in Manteia.
MGI - MGI:98731
RefSeq - NM_009373
RefSeq Peptide - NP_033399
swissprot - G3UXE8
swissprot - P21981
Ensembl - ENSMUSG00000037820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgm2aENSDARG00000070157Danio rerio
 tgm2bENSDARG00000074094Danio rerio
 TGM2ENSGALG00000006775Gallus gallus
 TGM2ENSG00000198959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgm5 / Q9D7I9 / Protein-glutamine gamma-glutamyltransferase 5 / O43548* / transglutaminase 5*ENSMUSG0000005367543
Tgm6 / transglutaminase 6 / O95932*ENSMUSG0000002740340
Tgm3 / Q08189 / Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-ca...ENSMUSG0000002740138
F13a1 / Q8BH61 / Coagulation factor XIII A chain / P00488*ENSMUSG0000003910936
Tgm7 / protein-glutamine gamma-glutamyltransferase Z / Q96PF1* / transglutaminase 7*ENSMUSG0000007910336
Tgm1 / transglutaminase 1 / P22735*ENSMUSG0000002221835
Epb42 / P49222 / Erythrocyte membrane protein band 4.2 / P16452*ENSMUSG0000002321633
Tgm4 / transglutaminase 4 / P49221*ENSMUSG0000002578730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001102  Transglutaminase, N-terminal
 IPR002931  Transglutaminase-like
 IPR008958  Transglutaminase, C-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013808  Transglutaminase, active site
 IPR014756  Immunoglobulin E-set
 IPR023608  Protein-glutamine gamma-glutamyltransferase, animal
 IPR036238  Transglutaminase, C-terminal domain superfamily
 IPR036985  Transglutaminase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IMP
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IMP
 biological_processGO:0060662 salivary gland cavitation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 molecular_functionGO:0003810 protein-glutamine gamma-glutamyltransferase activity ISO
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008483 transaminase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Tgm2tm1.1Rmgr/Tgm2+,Tg(HDexon1)62Gpb/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Apctm2Tno/Apc+
Genetic Background: involves: C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

Allelic Composition: Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Tgm2tm1.1Rmgr/Tgm2+,Tg(HDexon1)62Gpb/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0006110 ventricular fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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