ENSMUSG00000027401


Mus musculus

Features
Gene ID: ENSMUSG00000027401
  
Biological name :Tgm3
  
Synonyms : Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain / Q08189 / Tgm3
  
Possible biological names infered from orthology : Q08188 / transglutaminase 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 130012349
Gene end: 130050399
  
Corresponding Affymetrix probe sets: 10476042 (MoGene1.0st)   1421355_at (Mouse Genome 430 2.0 Array)   1440150_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105928
NCBI entrez gene - 21818     See in Manteia.
MGI - MGI:98732
RefSeq - XM_011239437
RefSeq - NM_009374
RefSeq - XM_006499151
RefSeq Peptide - NP_033400
swissprot - Q08189
Ensembl - ENSMUSG00000027401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgm5lENSDARG00000098837Danio rerio
 tgm8ENSDARG00000097651Danio rerio
 TGM3ENSGALG00000004804Gallus gallus
 TGM3ENSG00000125780Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgm6 / transglutaminase 6 / O95932*ENSMUSG0000002740350
Tgm5 / Q9D7I9 / Protein-glutamine gamma-glutamyltransferase 5 / O43548* / transglutaminase 5*ENSMUSG0000005367544
Tgm2 / P21981 / Protein-glutamine gamma-glutamyltransferase 2 / P21980* / transglutaminase 2*ENSMUSG0000003782038
Tgm7 / protein-glutamine gamma-glutamyltransferase Z / Q96PF1* / transglutaminase 7*ENSMUSG0000007910337
Tgm1 / transglutaminase 1 / P22735*ENSMUSG0000002221836
F13a1 / Q8BH61 / Coagulation factor XIII A chain / P00488*ENSMUSG0000003910933
Tgm4 / transglutaminase 4 / P49221*ENSMUSG0000002578731
Epb42 / P49222 / Erythrocyte membrane protein band 4.2 / P16452*ENSMUSG0000002321630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001102  Transglutaminase, N-terminal
 IPR002931  Transglutaminase-like
 IPR008958  Transglutaminase, C-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013808  Transglutaminase, active site
 IPR014756  Immunoglobulin E-set
 IPR023608  Protein-glutamine gamma-glutamyltransferase, animal
 IPR036238  Transglutaminase, C-terminal domain superfamily
 IPR036985  Transglutaminase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0018149 peptide cross-linking TAS
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0035315 hair cell differentiation TAS
 biological_processGO:0043163 cell envelope organization IEA
 biological_processGO:0043588 skin development TAS
 biological_processGO:0051262 protein tetramerization IEA
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 molecular_functionGO:0003810 protein-glutamine gamma-glutamyltransferase activity ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Lhx2tm1.1Lcar/Lhx2tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000396 increased curvature of hairs "distinct C- or S- shaped curvature of the hairs" [J:4606]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Tgm3we/Tgm3we
Genetic Background: Not Specified

Allelic Composition: Tgm3m1Btlr/Tgm3m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

Allelic Composition: Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Tgm3we/Tgm3we
Genetic Background: Not Specified

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001280 loss of vibrissae "inability to retain the whiskers" [J:45400]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Lhx2tm1.1Lcar/Lhx2tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx2tm1.1Lcar/Lhx2tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx2tm1.1Lcar/Lhx2tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx2tm1.1Lcar/Lhx2tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003848 brittle hair "hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008538 decreased zigzag hair amount "reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009351 thin hair shaft "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgm3we/Tgm3we
Genetic Background: Not Specified

 MP:0009441 delayed skin barrier formation "slowed progression in the establishment of the ability of the skin to regulate water loss" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009801 abnormal hair cortex keratinization "any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgm3tm1Sjo/Tgm3tm1Sjo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Bloc1s6pa/Bloc1s6pa,Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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