ENSMUSG00000039109


Mus musculus

Features
Gene ID: ENSMUSG00000039109
  
Biological name :F13a1
  
Synonyms : Coagulation factor XIII A chain / F13a1 / Q8BH61
  
Possible biological names infered from orthology : P00488
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 36867178
Gene end: 37050244
  
Corresponding Affymetrix probe sets: 10408693 (MoGene1.0st)   1448929_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048667
Ensembl peptide - ENSMUSP00000128316
NCBI entrez gene - 74145     See in Manteia.
MGI - MGI:1921395
RefSeq - NM_001166391
RefSeq - NM_028784
RefSeq Peptide - NP_001159863
RefSeq Peptide - NP_083060
swissprot - Q8BH61
Ensembl - ENSMUSG00000039109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F13A1 (1 of many)ENSDARG00000094832Danio rerio
 f13a1a.1ENSDARG00000045453Danio rerio
 f13a1bENSDARG00000036893Danio rerio
 F13A1ENSGALG00000012802Gallus gallus
 F13A1ENSG00000124491Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgm1 / transglutaminase 1 / P22735*ENSMUSG0000002221843
Tgm2 / P21981 / Protein-glutamine gamma-glutamyltransferase 2 / P21980* / transglutaminase 2*ENSMUSG0000003782034
Tgm6 / transglutaminase 6 / O95932*ENSMUSG0000002740333
Tgm5 / Q9D7I9 / Protein-glutamine gamma-glutamyltransferase 5 / O43548* / transglutaminase 5*ENSMUSG0000005367532
Tgm3 / Q08189 / Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-ca...ENSMUSG0000002740131
Tgm4 / transglutaminase 4 / P49221*ENSMUSG0000002578731
Tgm7 / protein-glutamine gamma-glutamyltransferase Z / Q96PF1* / transglutaminase 7*ENSMUSG0000007910326
Epb42 / P49222 / Erythrocyte membrane protein band 4.2 / P16452*ENSMUSG0000002321623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001102  Transglutaminase, N-terminal
 IPR002931  Transglutaminase-like
 IPR008958  Transglutaminase, C-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013808  Transglutaminase, active site
 IPR014756  Immunoglobulin E-set
 IPR023608  Protein-glutamine gamma-glutamyltransferase, animal
 IPR034810  Coagulation factor XIII A chain
 IPR036238  Transglutaminase, C-terminal domain superfamily
 IPR036985  Transglutaminase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0018149 peptide cross-linking ISS
 biological_processGO:0072378 blood coagulation, fibrin clot formation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003810 protein-glutamine gamma-glutamyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: F13a1tm1Gdi/F13a1tm1Gdi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F13a1tm1Gdi/F13a1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F13a1tm1Gdi/F13a1tm1Gdi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

Allelic Composition: F13a1tm1Gdi/F13a1tm1Gdi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

Allelic Composition: F13a1tm1Gdi/F13a1tm1Gdi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F13a1tm1Gdi/F13a1tm1Gdi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F13a1tm1Gdi/F13a1+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026368 F13b / Q07968 / Coagulation factor XIII B chain / P05160*  / complex
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000039109 F13a1 / Q8BH61 / Coagulation factor XIII A chain / P00488*  / complex






 

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