ENSG00000198959


Homo sapiens

Features
Gene ID: ENSG00000198959
  
Biological name :TGM2
  
Synonyms : P21980 / TGM2 / transglutaminase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.23
Gene start: 38127387
Gene end: 38166578
  
Corresponding Affymetrix probe sets: 201042_at (Human Genome U133 Plus 2.0 Array)   211003_x_at (Human Genome U133 Plus 2.0 Array)   211573_x_at (Human Genome U133 Plus 2.0 Array)   216183_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362502
Ensembl peptide - ENSP00000387642
Ensembl peptide - ENSP00000355330
NCBI entrez gene - 7052     See in Manteia.
OMIM - 190196
RefSeq - XM_011529028
RefSeq - NM_001323316
RefSeq - NM_001323317
RefSeq - NM_001323318
RefSeq - NM_004613
RefSeq - NM_198951
RefSeq Peptide - NP_004604
RefSeq Peptide - NP_945189
RefSeq Peptide - NP_001310246
RefSeq Peptide - NP_001310247
RefSeq Peptide - NP_001310245
swissprot - V9HWG3
swissprot - A2A2A0
swissprot - P21980
swissprot - A2A299
Ensembl - ENSG00000198959
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgm2aENSDARG00000070157Danio rerio
 tgm2bENSDARG00000074094Danio rerio
 TGM2ENSGALG00000006775Gallus gallus
 Tgm2ENSMUSG00000037820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TGM5 / O43548 / transglutaminase 5ENSG0000010405542
TGM7 / Q96PF1 / transglutaminase 7ENSG0000015949542
TGM6 / O95932 / transglutaminase 6ENSG0000016694841
TGM3 / Q08188 / transglutaminase 3ENSG0000012578038
F13A1 / P00488 / coagulation factor XIII A chainENSG0000012449137
TGM1 / P22735 / transglutaminase 1ENSG0000009229536
EPB42 / P16452 / erythrocyte membrane protein band 4.2ENSG0000016694733
TGM4 / P49221 / transglutaminase 4ENSG0000016381032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001102  Transglutaminase, N-terminal
 IPR002931  Transglutaminase-like
 IPR008958  Transglutaminase, C-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013808  Transglutaminase, active site
 IPR014756  Immunoglobulin E-set
 IPR023608  Protein-glutamine gamma-glutamyltransferase, animal
 IPR036238  Transglutaminase, C-terminal domain superfamily
 IPR036985  Transglutaminase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043277 apoptotic cell clearance IDA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IMP
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0060662 salivary gland cavitation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003810 protein-glutamine gamma-glutamyltransferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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