ENSMUSG00000038843


Mus musculus

Features
Gene ID: ENSMUSG00000038843
  
Biological name :Gcnt1
  
Synonyms : Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase / Gcnt1 / Q09324
  
Possible biological names infered from orthology : glucosaminyl (N-acetyl) transferase 1, core 2 / Q02742
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 17326141
Gene end: 17356667
  
Corresponding Affymetrix probe sets: 10466521 (MoGene1.0st)   1449538_a_at (Mouse Genome 430 2.0 Array)   1460431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127835
Ensembl peptide - ENSMUSP00000133935
NCBI entrez gene - 14537     See in Manteia.
MGI - MGI:95676
RefSeq - XM_017318062
RefSeq - NM_001136484
RefSeq - NM_010265
RefSeq - NM_173442
RefSeq - XM_006526679
RefSeq - XM_011247144
RefSeq Peptide - NP_001129956
RefSeq Peptide - NP_034395
RefSeq Peptide - NP_775618
swissprot - Q09324
Ensembl - ENSMUSG00000038843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GCNT1ENSGALG00000015166Gallus gallus
 GCNT1ENSG00000187210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcnt3 / Q5JCT0 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 / O95395* / glucosaminyl (N-acetyl) transferase 3, mucin type*ENSMUSG0000003222648
Gcnt4 / E9Q649 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 / Q9P109* / glucosaminyl (N-acetyl) transferase 4, core 2*ENSMUSG0000009138739
Gcnt2 / P97402 / N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase / Q8N0V5* / glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)*ENSMUSG0000002136034
Gcnt7 / Q3V3K7 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 / Q6ZNI0* / glucosaminyl (N-acetyl) transferase family member 7*ENSMUSG0000007456927
Xylt1 / xylosyltransferase 1 / Q86Y38*ENSMUSG0000003065721
Xylt2 / Q9EPL0 / xylosyltransferase II / Q9H1B5* / xylosyltransferase 2*ENSMUSG0000002086821


Protein motifs (from Interpro)
Interpro ID Name
 IPR003406  Glycosyl transferase, family 14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0009101 glycoprotein biosynthetic process ISS
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0048729 tissue morphogenesis IGI
 biological_processGO:0050901 leukocyte tethering or rolling ISS
 biological_processGO:0060352 cell adhesion molecule production ISO
 biological_processGO:0060993 kidney morphogenesis IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031985 Golgi cisterna ISS
 molecular_functionGO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr6tm1Lex/Cxcr6+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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