ENSMUSG00000020868


Mus musculus

Features
Gene ID: ENSMUSG00000020868
  
Biological name :Xylt2
  
Synonyms : Q9EPL0 / xylosyltransferase II / Xylt2
  
Possible biological names infered from orthology : Q9H1B5 / xylosyltransferase 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 94663851
Gene end: 94677515
  
Corresponding Affymetrix probe sets: 10390059 (MoGene1.0st)   1452515_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112052
Ensembl peptide - ENSMUSP00000122581
Ensembl peptide - ENSMUSP00000122728
Ensembl peptide - ENSMUSP00000134495
NCBI entrez gene - 217119     See in Manteia.
MGI - MGI:2444797
RefSeq - XM_017314479
RefSeq - NM_145828
RefSeq - XM_017314478
RefSeq Peptide - NP_665827
swissprot - F2Z434
swissprot - Q9EPL0
swissprot - G3UZH1
swissprot - F2Z436
Ensembl - ENSMUSG00000020868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xylt2ENSDARG00000059557Danio rerio
 XYLT2ENSGALG00000007702Gallus gallus
 XYLT2ENSG00000015532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xylt1 / xylosyltransferase 1 / Q86Y38*ENSMUSG0000003065755
Gcnt3 / Q5JCT0 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 / O95395* / glucosaminyl (N-acetyl) transferase 3, mucin type*ENSMUSG0000003222610
Gcnt2 / P97402 / N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase / Q8N0V5* / glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)*ENSMUSG0000002136010
Gcnt1 / Q09324 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase / Q02742* / glucosaminyl (N-acetyl) transferase 1, core 2*ENSMUSG0000003884310
Gcnt4 / E9Q649 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 / Q9P109* / glucosaminyl (N-acetyl) transferase 4, core 2*ENSMUSG0000009138710
Gcnt7 / Q3V3K7 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 / Q6ZNI0* / glucosaminyl (N-acetyl) transferase family member 7*ENSMUSG000000745698


Protein motifs (from Interpro)
Interpro ID Name
 IPR003406  Glycosyl transferase, family 14
 IPR024448  Xylosyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process ISO
 biological_processGO:0030166 proteoglycan biosynthetic process IMP
 biological_processGO:0030206 chondroitin sulfate biosynthetic process IEA
 biological_processGO:0030210 heparin biosynthetic process IMP
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030158 protein xylosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0003327 liver cysts "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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