ENSMUSG00000032226


Mus musculus

Features
Gene ID: ENSMUSG00000032226
  
Biological name :Gcnt3
  
Synonyms : Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 / Gcnt3 / Q5JCT0
  
Possible biological names infered from orthology : glucosaminyl (N-acetyl) transferase 3, mucin type / O95395
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 70031496
Gene end: 70038088
  
Corresponding Affymetrix probe sets: 10594758 (MoGene1.0st)   1424901_at (Mouse Genome 430 2.0 Array)   1430963_at (Mouse Genome 430 2.0 Array)   1440409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034751
NCBI entrez gene - 72077     See in Manteia.
MGI - MGI:1919327
RefSeq - XM_011242817
RefSeq - NM_028087
RefSeq - XM_011242815
RefSeq - XM_011242816
RefSeq - XM_006511463
RefSeq - XM_006511465
RefSeq Peptide - NP_082363
swissprot - Q5JCT0
Ensembl - ENSMUSG00000032226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcnt3ENSDARG00000060471Danio rerio
 GCNT3ENSGALG00000044940Gallus gallus
 GCNT3ENSG00000140297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcnt1 / Q09324 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase / Q02742* / glucosaminyl (N-acetyl) transferase 1, core 2*ENSMUSG0000003884347
Gcnt4 / E9Q649 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 / Q9P109* / glucosaminyl (N-acetyl) transferase 4, core 2*ENSMUSG0000009138739
Gcnt2 / P97402 / N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase / Q8N0V5* / glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)*ENSMUSG0000002136036
Gcnt7 / Q3V3K7 / Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 / Q6ZNI0* / glucosaminyl (N-acetyl) transferase family member 7*ENSMUSG0000007456929
Xylt2 / Q9EPL0 / xylosyltransferase II / Q9H1B5* / xylosyltransferase 2*ENSMUSG0000002086820
Xylt1 / xylosyltransferase 1 / Q86Y38*ENSMUSG0000003065719


Protein motifs (from Interpro)
Interpro ID Name
 IPR003406  Glycosyl transferase, family 14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002426 immunoglobulin production in mucosal tissue IMP
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation ISO
 biological_processGO:0048729 tissue morphogenesis IGI
 biological_processGO:0050892 intestinal absorption IMP
 biological_processGO:0060993 kidney morphogenesis IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IMP


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dkc1tm2Pjma/Y
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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