ENSMUSG00000040025


Mus musculus

Features
Gene ID: ENSMUSG00000040025
  
Biological name :Ythdf2
  
Synonyms : Q91YT7 / Ythdf2 / YTH domain family 2
  
Possible biological names infered from orthology : Q9Y5A9 / YTH N6-methyladenosine RNA binding protein 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132184912
Gene end: 132212303
  
Corresponding Affymetrix probe sets: 10516859 (MoGene1.0st)   1451317_at (Mouse Genome 430 2.0 Array)   1460357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120414
Ensembl peptide - ENSMUSP00000129225
Ensembl peptide - ENSMUSP00000082275
NCBI entrez gene - 213541     See in Manteia.
MGI - MGI:2444233
RefSeq - NM_145393
RefSeq Peptide - NP_663368
swissprot - Q91YT7
swissprot - E9PW90
swissprot - F6Y6H7
Ensembl - ENSMUSG00000040025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7F1H9ENSDARG00000014498Danio rerio
 YTHDF2ENSGALG00000034831Gallus gallus
 Q9Y5A9ENSG00000198492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BYK6 / Ythdf3 / YTH domain family 3 / Q7Z739* / YTH N6-methyladenosine RNA binding protein 3*ENSMUSG0000004721367
P59326 / Ythdf1 / YTH domain family 1 / Q9BYJ9* / YTH N6-methyladenosine RNA binding protein 1*ENSMUSG0000003884864


Protein motifs (from Interpro)
Interpro ID Name
 IPR007275  YTH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway ISS
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0048598 embryonic morphogenesis ISS
 biological_processGO:0061157 mRNA destabilization IEA
 biological_processGO:0098508 endothelial to hematopoietic transition ISS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation ISS
 biological_processGO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation IMP
 biological_processGO:1903679 positive regulation of cap-independent translational initiation IEA
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:1990247 N6-methyladenosine-containing RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

Allelic Composition: Ythdf2tm1.2Doca/Ythdf2tm1.2Doca
Genetic Background: involves: FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ythdf2tm1.2Doca/Ythdf2tm1.2Doca
Genetic Background: involves: FVB/N

Allelic Composition: Ythdf2tm1.2Doca/Ythdf2tm1.2Doca
Genetic Background: B6.Cg-Ythdf2tm1.2Doca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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