ENSMUSG00000040724


Mus musculus

Features
Gene ID: ENSMUSG00000040724
  
Biological name :Kcna2
  
Synonyms : Kcna2 / P63141 / Potassium voltage-gated channel subfamily A member 2
  
Possible biological names infered from orthology : P16389
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.3
Gene start: 107101146
Gene end: 107115005
  
Corresponding Affymetrix probe sets: 10495193 (MoGene1.0st)   10495197 (MoGene1.0st)   1422197_at (Mouse Genome 430 2.0 Array)   1439872_at (Mouse Genome 430 2.0 Array)   1440759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041702
Ensembl peptide - ENSMUSP00000142873
Ensembl peptide - ENSMUSP00000143798
NCBI entrez gene - 16490     See in Manteia.
MGI - MGI:96659
RefSeq - XM_006501055
RefSeq - NM_008417
RefSeq - XM_006501053
RefSeq - XM_006501054
RefSeq - XM_006501048
RefSeq - XM_006501049
RefSeq - XM_006501050
RefSeq - XM_006501051
RefSeq - XM_006501052
RefSeq Peptide - NP_032443
swissprot - P63141
Ensembl - ENSMUSG00000040724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcna2aENSDARG00000002241Danio rerio
 kcna2bENSDARG00000102064Danio rerio
 KCNA2ENSGALG00000000442Gallus gallus
 KCNA2ENSG00000177301Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcna3 / P16390 / Potassium voltage-gated channel subfamily A member 3 / P22001*ENSMUSG0000004795978
Kcna1 / P16388 / Potassium voltage-gated channel subfamily A member 1 / Q09470*ENSMUSG0000004797678
Kcna4 / Q61423 / Potassium voltage-gated channel subfamily A member 4 / P22459*ENSMUSG0000004260470
Kcna5 / Q61762 / Potassium voltage-gated channel subfamily A member 5 / P22460*ENSMUSG0000004553468
Kcna6 / Q61923 / Potassium voltage-gated channel subfamily A member 6 / P17658*ENSMUSG0000003807767
B2RQA1 / Kcna10 / Potassium voltage-gated channel subfamily A member 10 / Q16322*ENSMUSG0000004286160
Kcna7 / Q17ST2 / Potassium voltage-gated channel subfamily A member 7 / Q96RP8*ENSMUSG0000003820159
Kcnc2 / Q14B80 / Potassium voltage-gated channel subfamily C member 2 / Q96PR1*ENSMUSG0000003568137
Kcnc4 / Q8R1C0 / Potassium voltage-gated channel subfamily C member 4 / Q03721*ENSMUSG0000002789537
Kcnc3 / potassium voltage-gated channel subfamily C member 3 isoform 2 / Q14003* / potassium voltage-gated channel subfamily C member 3*ENSMUSG0000006278536
Kcnc1 / P15388 / Potassium voltage-gated channel subfamily C member 1 / P48547*ENSMUSG0000005897535
Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*ENSMUSG0000006088235
Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*ENSMUSG0000000973135
Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*ENSMUSG0000004089634


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003972  Potassium channel, voltage dependent, Kv1
 IPR004049  Potassium channel, voltage dependent, Kv1.2
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0019228 neuronal action potential ISS
 biological_processGO:0019233 sensory perception of pain ISS
 biological_processGO:0021633 optic nerve structural organization IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep IMP
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IDA
 cellular_componentGO:0033010 paranodal junction IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0044224 juxtaparanode region of axon IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity ISS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA
 molecular_functionGO:0019894 kinesin binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Kcna2Pgu/Kcna2Pgu
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010540 long stride length "increased average distance between steps" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: C3Fe.129S7-Kcna2tm1Tem

Allelic Composition: Kcna2tm1Tem/Kcna2tm1Tem
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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