ENSMUSG00000045534


Mus musculus

Features
Gene ID: ENSMUSG00000045534
  
Biological name :Kcna5
  
Synonyms : Kcna5 / Potassium voltage-gated channel subfamily A member 5 / Q61762
  
Possible biological names infered from orthology : P22460
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 126532551
Gene end: 126535412
  
Corresponding Affymetrix probe sets: 10548043 (MoGene1.0st)   1417680_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055673
NCBI entrez gene - 16493     See in Manteia.
MGI - MGI:96662
RefSeq - NM_145983
RefSeq Peptide - NP_666095
swissprot - Q61762
Ensembl - ENSMUSG00000045534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNA5ENSG00000130037Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcna4 / Q61423 / Potassium voltage-gated channel subfamily A member 4 / P22459*ENSMUSG0000004260457
Kcna2 / P63141 / Potassium voltage-gated channel subfamily A member 2 / P16389*ENSMUSG0000004072456
Kcna6 / Q61923 / Potassium voltage-gated channel subfamily A member 6 / P17658*ENSMUSG0000003807756
Kcna3 / P16390 / Potassium voltage-gated channel subfamily A member 3 / P22001*ENSMUSG0000004795955
Kcna1 / P16388 / Potassium voltage-gated channel subfamily A member 1 / Q09470*ENSMUSG0000004797655
B2RQA1 / Kcna10 / Potassium voltage-gated channel subfamily A member 10 / Q16322*ENSMUSG0000004286152
Kcna7 / Q17ST2 / Potassium voltage-gated channel subfamily A member 7 / Q96RP8*ENSMUSG0000003820147
Kcnc3 / potassium voltage-gated channel subfamily C member 3 isoform 2 / Q14003* / potassium voltage-gated channel subfamily C member 3*ENSMUSG0000006278531
Kcnc2 / Q14B80 / Potassium voltage-gated channel subfamily C member 2 / Q96PR1*ENSMUSG0000003568130
Kcnc4 / Q8R1C0 / Potassium voltage-gated channel subfamily C member 4 / Q03721*ENSMUSG0000002789530
Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*ENSMUSG0000004089629
Kcnc1 / P15388 / Potassium voltage-gated channel subfamily C member 1 / P48547*ENSMUSG0000005897529
Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*ENSMUSG0000006088229
Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*ENSMUSG0000000973129


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003972  Potassium channel, voltage dependent, Kv1
 IPR004052  Potassium channel, voltage dependent, Kv1.5
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport ISO
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0019229 regulation of vasoconstriction IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043266 regulation of potassium ion transport IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IDA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0055075 potassium ion homeostasis IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0060372 regulation of atrial cardiac muscle cell membrane repolarization IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071435 potassium ion export IEA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0086014 atrial cardiac muscle cell action potential IEA
 biological_processGO:0086050 membrane repolarization during bundle of His cell action potential IEA
 biological_processGO:0086052 membrane repolarization during SA node cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098914 membrane repolarization during atrial cardiac muscle cell action potential IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000288 positive regulation of myoblast proliferation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046691 intracellular canaliculus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA
 molecular_functionGO:0019870 potassium channel inhibitor activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA
 molecular_functionGO:0086087 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization IEA
 molecular_functionGO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
 molecular_functionGO:0086090 voltage-gated potassium channel activity involved in SA node cell action potential repolarization IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Bicc1jcpk/T(2;10)67Gso
Genetic Background: involves: 101 * C3H * C3H/Rl * C57BL/6 * C57BL/RlGso * SEC/RlGso

 MP:0003488 decreased channel response intensity 
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fignfi/Fignfi
Genetic Background: mixed

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bicc1jcpk/T(2;10)67Gso
Genetic Background: involves: 101 * C3H * C3H/Rl * C57BL/6 * C57BL/RlGso * SEC/RlGso

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1jcpk/T(2;10)67Gso
Genetic Background: involves: 101 * C3H * C3H/Rl * C57BL/6 * C57BL/RlGso * SEC/RlGso

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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