ENSMUSG00000047959


Mus musculus

Features
Gene ID: ENSMUSG00000047959
  
Biological name :Kcna3
  
Synonyms : Kcna3 / P16390 / Potassium voltage-gated channel subfamily A member 3
  
Possible biological names infered from orthology : P22001
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.3
Gene start: 107036169
Gene end: 107038070
  
Corresponding Affymetrix probe sets: 10495183 (MoGene1.0st)   1423018_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050680
NCBI entrez gene - 16491     See in Manteia.
MGI - MGI:96660
RefSeq - NM_008418
RefSeq Peptide - NP_032444
swissprot - P16390
Ensembl - ENSMUSG00000047959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNA3ENSGALG00000036942Gallus gallus
 KCNA3ENSG00000177272Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcna2 / P63141 / Potassium voltage-gated channel subfamily A member 2 / P16389*ENSMUSG0000004072474
Kcna1 / P16388 / Potassium voltage-gated channel subfamily A member 1 / Q09470*ENSMUSG0000004797670
Kcna4 / Q61423 / Potassium voltage-gated channel subfamily A member 4 / P22459*ENSMUSG0000004260465
Kcna6 / Q61923 / Potassium voltage-gated channel subfamily A member 6 / P17658*ENSMUSG0000003807763
Kcna5 / Q61762 / Potassium voltage-gated channel subfamily A member 5 / P22460*ENSMUSG0000004553463
B2RQA1 / Kcna10 / Potassium voltage-gated channel subfamily A member 10 / Q16322*ENSMUSG0000004286157
Kcna7 / Q17ST2 / Potassium voltage-gated channel subfamily A member 7 / Q96RP8*ENSMUSG0000003820157
Kcnc4 / Q8R1C0 / Potassium voltage-gated channel subfamily C member 4 / Q03721*ENSMUSG0000002789535
Kcnc1 / P15388 / Potassium voltage-gated channel subfamily C member 1 / P48547*ENSMUSG0000005897534
Kcnc3 / potassium voltage-gated channel subfamily C member 3 isoform 2 / Q14003* / potassium voltage-gated channel subfamily C member 3*ENSMUSG0000006278534
Kcnc2 / Q14B80 / Potassium voltage-gated channel subfamily C member 2 / Q96PR1*ENSMUSG0000003568134
Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*ENSMUSG0000000973133
Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*ENSMUSG0000006088233
Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*ENSMUSG0000004089632


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003972  Potassium channel, voltage dependent, Kv1
 IPR004050  Potassium channel, voltage dependent, Kv1.3
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Krt71Rgsc689/?
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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