ENSMUSG00000040836


Mus musculus

Features
Gene ID: ENSMUSG00000040836
  
Biological name :Gpr161
  
Synonyms : B2RPY5 / Gpr161 / G protein-coupled receptor 161
  
Possible biological names infered from orthology : Q8N6U8
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.2
Gene start: 165295789
Gene end: 165326745
  
Corresponding Affymetrix probe sets: 10351298 (MoGene1.0st)   1436459_at (Mouse Genome 430 2.0 Array)   1447353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136621
Ensembl peptide - ENSMUSP00000107077
NCBI entrez gene - 240888     See in Manteia.
MGI - MGI:2685054
RefSeq - XM_011238821
RefSeq - NM_001310429
RefSeq - NM_001310430
RefSeq - XM_006496850
RefSeq - XM_006496851
RefSeq - XM_006496852
RefSeq - NM_001081126
RefSeq Peptide - NP_001297358
RefSeq Peptide - NP_001297359
RefSeq Peptide - NP_001074595
swissprot - B2RPY5
swissprot - A0A140T8Q9
Ensembl - ENSMUSG00000040836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr161ENSDARG00000055659Danio rerio
 si:ch211-237c6.4ENSDARG00000058903Danio rerio
 GPR161ENSGALG00000015247Gallus gallus
 GPR161ENSG00000143147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr101 / Q80T62 / G protein-coupled receptor 101 / Q96P66*ENSMUSG0000003635716
Gpr45 / Q9EQQ4 / Probable G-protein coupled receptor 45 / Q9Y5Y3* / G protein-coupled receptor 45*ENSMUSG0000004190715
Gpr63 / Q9EQQ3 / Probable G-protein coupled receptor 63 / Q9BZJ6* / G protein-coupled receptor 63*ENSMUSG0000004037213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IMP
 biological_processGO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Bhr/Prrx1tm1Bhr
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Gpr161vl/Gpr161vl
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Gpr161vl/Gpr161vl,Modvl3MOLF/EiJ/Modvl3MOLF/EiJ
Genetic Background: involves: C3H/HeSnJ * MOLF/EiJ

Allelic Composition: Gpr161vl/Gpr161vl,Modvl3C3H/HeSnJ/Modvl3MOLF/EiJ
Genetic Background: involves: C3H/HeSnJ * MOLF/EiJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6N

 MP:0001677 absent apical ectodermal ridge "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [J:54637]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6N

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6N

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Gpr161vl/Gpr161vl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

Allelic Composition: Gpr161vl/Gpr161vl
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

Allelic Composition: Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C3H/HeSnJ
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

Allelic Composition: Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C57BL/6J
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

Allelic Composition: Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2C3H/HeSnJ
Genetic Background: involves: C3H/HeSnJ * CAST/EiJ

Allelic Composition: Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2CAST/EiJ
Genetic Background: involves: C3H/HeSnJ * CAST/EiJ

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex
Genetic Background: involves: 129S/SvEv * C57BL/6N

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex,Kif3atm1Gsn/Kif3atm1Gsn
Genetic Background: involves: 129 * C57BL/6N

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex
Genetic Background: involves: 129S/SvEv * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex
Genetic Background: involves: 129S/SvEv * C57BL/6N

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
Show

Allelic Composition: Gpr161tm1Lex/Gpr161tm1Lex
Genetic Background: involves: 129S/SvEv * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001521 Tulp3 / O88413 / tubby-like protein 3 / O75386*  / complex / reaction
 ENSMUSG00000024169 E9PY46 / Ift140 / Intraflagellar transport / Q96RY7* / intraflagellar transport 140*  / complex / reaction
 ENSMUSG00000030323 Ift122 / Q6NWV3 / Intraflagellar transport / Q9HBG6* / intraflagellar transport 122*  / complex / reaction
 ENSMUSG00000037890 Wdr19 / Q3UGF1 / WD repeat domain 19 / Q8NEZ3*  / reaction / complex
 ENSMUSG00000066643 Wdr35 / Q8BND3 / WD repeat domain 35 / Q9P2L0*  / reaction / complex
 ENSMUSG00000034848 Q0HA38 / Ttc21b / tetratricopeptide repeat domain 21B / Q7Z4L5*  / complex / reaction






 

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