ENSMUSG00000037890


Mus musculus

Features
Gene ID: ENSMUSG00000037890
  
Biological name :Wdr19
  
Synonyms : Q3UGF1 / Wdr19 / WD repeat domain 19
  
Possible biological names infered from orthology : Q8NEZ3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65199696
Gene end: 65260415
  
Corresponding Affymetrix probe sets: 10522090 (MoGene1.0st)   1455669_at (Mouse Genome 430 2.0 Array)   1459034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144866
Ensembl peptide - ENSMUSP00000038098
Ensembl peptide - ENSMUSP00000144826
NCBI entrez gene - 213081     See in Manteia.
MGI - MGI:2443231
RefSeq - NM_153391
RefSeq - XM_011240713
RefSeq Peptide - NP_700440
swissprot - A0A0N4SUU5
swissprot - Q3UGF1
Ensembl - ENSMUSG00000037890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr19ENSDARG00000037406Danio rerio
 WDR19ENSGALG00000014064Gallus gallus
 WDR19ENSG00000157796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0008406 gonad development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0035721 intraciliary retrograde transport IBA
 biological_processGO:0042471 ear morphogenesis IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0050877 nervous system process IMP
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0060830 ciliary receptor clustering involved in smoothened signaling pathway IGI
 biological_processGO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
 biological_processGO:0061055 myotome development IMP
 biological_processGO:0061512 protein localization to cilium ISO
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0030991 intraciliary transport particle A ISS
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

Allelic Composition: Wdr19dmhd/Wdr19dmhd
Genetic Background: involves: FVB/NJ

 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000568 ectopic digits "positional abnormality of a digit" [J:50311]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0002820 abnormal premaxilla morphology "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004376 absent frontal bone "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004420 parietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004443 absent supraoccipital bone "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0009895 decreased palatine shelf size "reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

Allelic Composition: Wdr19dmhd/Wdr19dmhd
Genetic Background: involves: FVB/NJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

Allelic Composition: Wdr19dmhd/Wdr19twto
Genetic Background: involves: FVB/NJ

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

 MP:0011685 abnormal limb paddle morphology "any structural anomaly of the transient developing limb structure that develops from the limb bud; it is a dorsoventral flattening of the limb bud structure and develops into the foot plate" [MGI:csmith]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

Allelic Composition: Wdr19dmhd/Wdr19dmhd
Genetic Background: involves: FVB/NJ

Allelic Composition: Wdr19dmhd/Wdr19twto
Genetic Background: involves: FVB/NJ

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-6J
Genetic Background: (B6.C3-Ap3b1pe x C3H/HeJ-Ap3b1pe-6J)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030323 Ift122 / Q6NWV3 / Intraflagellar transport / Q9HBG6* / intraflagellar transport 122*  / complex
 ENSMUSG00000040836 B2RPY5 / Gpr161 / G protein-coupled receptor 161 / Q8N6U8*  / reaction / complex
 ENSMUSG00000024169 E9PY46 / Ift140 / Intraflagellar transport / Q96RY7* / intraflagellar transport 140*  / complex
 ENSMUSG00000034848 Q0HA38 / Ttc21b / tetratricopeptide repeat domain 21B / Q7Z4L5*  / complex
 ENSMUSG00000001521 Tulp3 / O88413 / tubby-like protein 3 / O75386*  / complex / reaction
 ENSMUSG00000066643 Wdr35 / Q8BND3 / WD repeat domain 35 / Q9P2L0*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr