ENSMUSG00000066643


Mus musculus

Features
Gene ID: ENSMUSG00000066643
  
Biological name :Wdr35
  
Synonyms : Q8BND3 / Wdr35 / WD repeat domain 35
  
Possible biological names infered from orthology : Q9P2L0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 8973892
Gene end: 9028847
  
Corresponding Affymetrix probe sets: 10394498 (MoGene1.0st)   1440318_at (Mouse Genome 430 2.0 Array)   1454790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082895
Ensembl peptide - ENSMUSP00000106742
Ensembl peptide - ENSMUSP00000124285
NCBI entrez gene - 74682     See in Manteia.
MGI - MGI:1921932
RefSeq - XM_006515232
RefSeq - NM_001159527
RefSeq - NM_172470
RefSeq Peptide - NP_001152999
RefSeq Peptide - NP_766058
swissprot - Q8BND3
swissprot - E0CYD5
Ensembl - ENSMUSG00000066643
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr35ENSDARG00000069269Danio rerio
 ENSGALG00000016477Gallus gallus
 ENSGALG00000038544Gallus gallus
 WDR35ENSG00000118965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tulp4 / Q9JIL5 / tubby like protein 4 / Q9NRJ4*ENSMUSG0000003437712
Tub / P50586 / tubby bipartite transcription factor / P50607*ENSMUSG000000310289
Tulp3 / O88413 / tubby-like protein 3 / O75386*ENSMUSG000000015218
Tulp2 / P46686 / tubby-like protein 2 / O00295*ENSMUSG000000234678
Tulp1 / Q9Z273 / tubby like protein 1 / O00294*ENSMUSG000000374468


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017233  WD repeat protein 35
 IPR017986  WD40-repeat-containing domain
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035721 intraciliary retrograde transport IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0061512 protein localization to cilium IBA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:1901555 response to paclitaxel IEA
 biological_processGO:1905705 cellular response to paclitaxel IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0030991 intraciliary transport particle A ISS
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000151 absent rib "missing the pairs of bony structures that make up the body wall" [J:19212]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myod1tm2.1Glh/Myod1tm2.1Glh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024169 E9PY46 / Ift140 / Intraflagellar transport / Q96RY7* / intraflagellar transport 140*  / complex
 ENSMUSG00000030323 Ift122 / Q6NWV3 / Intraflagellar transport / Q9HBG6* / intraflagellar transport 122*  / complex
 ENSMUSG00000037890 Wdr19 / Q3UGF1 / WD repeat domain 19 / Q8NEZ3*  / complex
 ENSMUSG00000034848 Q0HA38 / Ttc21b / tetratricopeptide repeat domain 21B / Q7Z4L5*  / complex
 ENSMUSG00000040836 B2RPY5 / Gpr161 / G protein-coupled receptor 161 / Q8N6U8*  / reaction / complex
 ENSMUSG00000001521 Tulp3 / O88413 / tubby-like protein 3 / O75386*  / reaction / complex






 

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