ENSMUSG00000031028


Mus musculus

Features
Gene ID: ENSMUSG00000031028
  
Biological name :Tub
  
Synonyms : P50586 / Tub / tubby bipartite transcription factor
  
Possible biological names infered from orthology : P50607
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 108950338
Gene end: 109034460
  
Corresponding Affymetrix probe sets: 10556178 (MoGene1.0st)   1420925_at (Mouse Genome 430 2.0 Array)   1450041_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146894
Ensembl peptide - ENSMUSP00000033341
Ensembl peptide - ENSMUSP00000113580
NCBI entrez gene - 22141     See in Manteia.
MGI - MGI:2651573
RefSeq - NM_021885
RefSeq Peptide - NP_068685
swissprot - A0A0R4J1P1
swissprot - P50586
swissprot - Q3UEX1
swissprot - Q4VA41
Ensembl - ENSMUSG00000031028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubENSDARG00000062165Danio rerio
 TUBENSGALG00000005986Gallus gallus
 TUBENSG00000166402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tulp3 / O88413 / tubby-like protein 3 / O75386*ENSMUSG0000000152154
Tulp1 / Q9Z273 / tubby like protein 1 / O00294*ENSMUSG0000003744647
Tulp2 / P46686 / tubby-like protein 2 / O00295*ENSMUSG0000002346741
Tulp4 / Q9JIL5 / tubby like protein 4 / Q9NRJ4*ENSMUSG0000003437725
Wdr35 / Q8BND3 / WD repeat domain 35 / Q9P2L0*ENSMUSG0000006664321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000007  Tubby, C-terminal
 IPR005398  Tubby, N-terminal
 IPR018066  Tubby, C-terminal, conserved site
 IPR025659  Tubby-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006910 phagocytosis, recognition IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0097500 receptor localization to non-motile cilium IMP
 biological_processGO:1903441 protein localization to ciliary membrane ISO
 biological_processGO:1903546 protein localization to photoreceptor outer segment IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppp1r15atm1Kii/Ppp1r15atm1Kii
Genetic Background: involves: 129P2/OlaHsd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Tshrm1Btlr/Tshrm1Btlr
Genetic Background: C57BL/6J-Tshrm1Btlr

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003151 absent tunnel of Corti "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004289 abnormal bony labyrinth "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006187 retinal deposits "abnormal accumulation of material on the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtub/Tubtub,Tulp1tm1Pjn/Tulp1tm1Pjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtub/Tubtub
Genetic Background: C57BL/6J-Tubtub

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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