ENSMUSG00000041298


Mus musculus

Features
Gene ID: ENSMUSG00000041298
  
Biological name :Katnal1
  
Synonyms : Katanin p60 ATPase-containing subunit A-like 1 / Katnal1 / Q8K0T4
  
Possible biological names infered from orthology : katanin catalytic subunit A1 like 1 / Q9BW62
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 148871584
Gene end: 148929320
  
Corresponding Affymetrix probe sets: 10535883 (MoGene1.0st)   1439606_at (Mouse Genome 430 2.0 Array)   1442348_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120707
Ensembl peptide - ENSMUSP00000043210
Ensembl peptide - ENSMUSP00000106136
NCBI entrez gene - 231912     See in Manteia.
MGI - MGI:2387638
RefSeq - XM_006504828
RefSeq - XM_006504829
RefSeq - NM_153572
RefSeq Peptide - NP_705800
swissprot - Q8K0T4
swissprot - G5E8P9
swissprot - D3YWJ8
Ensembl - ENSMUSG00000041298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 katnal1ENSDARG00000099156Danio rerio
 KATNAL1ENSGALG00000017083Gallus gallus
 Q9BW62ENSG00000102781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Katna1 / katanin catalytic subunit A1 / O75449*ENSMUSG0000001979467
Gm42791 / Q9BW62* / KATNAL1* / katanin catalytic subunit A1 like 1*ENSMUSG0000010689243
Vps4a / Q8VEJ9 / vacuolar protein sorting 4A / Q9UN37* / AC026464.4* / vacuolar protein sorting 4 homolog A*ENSMUSG0000003191334
Vps4b / P46467 / vacuolar protein sorting 4B / O75351* / vacuolar protein sorting 4 homolog B*ENSMUSG0000000990732
Q9D3R6 / Katnal2 / Katanin p60 ATPase-containing subunit A-like 2 / Q8IYT4* / katanin catalytic subunit A1 like 2*ENSMUSG0000002542026


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028594  Katanin p60 subunit A-like 1, chordates
 IPR028596  Katanin p60 subunit A1
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0051013 microtubule severing ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008568 microtubule-severing ATPase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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