ENSMUSG00000031913


Mus musculus

Features
Gene ID: ENSMUSG00000031913
  
Biological name :Vps4a
  
Synonyms : Q8VEJ9 / vacuolar protein sorting 4A / Vps4a
  
Possible biological names infered from orthology : AC026464.4 / Q9UN37 / vacuolar protein sorting 4 homolog A
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 107031222
Gene end: 107045755
  
Corresponding Affymetrix probe sets: 10575129 (MoGene1.0st)   1417510_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034388
NCBI entrez gene - 116733     See in Manteia.
MGI - MGI:1890520
RefSeq - NM_126165
RefSeq Peptide - NP_569053
swissprot - Q8VEJ9
Ensembl - ENSMUSG00000031913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps4aENSDARG00000030114Danio rerio
 ENSGALG00000040713Gallus gallus
 AC026464.4ENSG00000260914Homo sapiens
 VPS4AENSG00000132612Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vps4b / P46467 / vacuolar protein sorting 4B / O75351* / vacuolar protein sorting 4 homolog B*ENSMUSG0000000990782
Q8K0T4 / Katnal1 / Katanin p60 ATPase-containing subunit A-like 1 / Q9BW62* / katanin catalytic subunit A1 like 1*ENSMUSG0000004129838
Katna1 / katanin catalytic subunit A1 / O75449*ENSMUSG0000001979437
Q9D3R6 / Katnal2 / Katanin p60 ATPase-containing subunit A-like 2 / Q8IYT4* / katanin catalytic subunit A1 like 2*ENSMUSG0000002542025
Gm42791 / Q9BW62* / KATNAL1* / katanin catalytic subunit A1 like 1*ENSMUSG000001068927


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000920 cell separation after cytokinesis ISO
 biological_processGO:0006622 protein targeting to lysosome ISO
 biological_processGO:0006900 vesicle budding from membrane ISO
 biological_processGO:0006997 nucleus organization ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression ISO
 biological_processGO:0009838 abscission ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport ISO
 biological_processGO:0016197 endosomal transport ISO
 biological_processGO:0019076 viral release from host cell ISO
 biological_processGO:0032367 intracellular cholesterol transport ISO
 biological_processGO:0032466 negative regulation of cytokinesis ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0034058 endosomal vesicle fusion ISO
 biological_processGO:0036258 multivesicular body assembly IMP
 biological_processGO:0039702 viral budding via host ESCRT complex ISO
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
 biological_processGO:0044878 mitotic cytokinesis checkpoint ISO
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0051301 cell division ISO
 biological_processGO:0061738 late endosomal microautophagy IMP
 biological_processGO:0072319 vesicle uncoating ISO
 biological_processGO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
 biological_processGO:1902188 positive regulation of viral release from host cell ISO
 biological_processGO:1903076 regulation of protein localization to plasma membrane ISO
 biological_processGO:1903543 positive regulation of exosomal secretion ISO
 biological_processGO:1903774 positive regulation of viral budding via host ESCRT complex ISO
 biological_processGO:1903902 positive regulation of viral life cycle ISO
 cellular_componentGO:0000815 ESCRT III complex ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005774 vacuolar membrane ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0090543 Flemming body ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0019904 protein domain specific binding ISO


Pathways (from Reactome)
Pathway description
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0009908 protruding tongue "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019868 Vta1 / Q9CR26 / vesicle (multivesicular body) trafficking 1 / Q9NP79* / vesicle trafficking 1*  / complex
 ENSMUSG00000028419 Chmp5 / Q9D7S9 / Charged multivesicular body protein 5 / Q9NZZ3*  / complex
 ENSMUSG00000009907 Vps4b / P46467 / vacuolar protein sorting 4B / O75351* / vacuolar protein sorting 4 homolog B*  / complex






 

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