ENSG00000132612


Homo sapiens

Features
Gene ID: ENSG00000132612
  
Biological name :VPS4A
  
Synonyms : Q9UN37 / vacuolar protein sorting 4 homolog A / VPS4A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 69311356
Gene end: 69326939
  
Corresponding Affymetrix probe sets: 217913_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254950
NCBI entrez gene - 27183     See in Manteia.
OMIM - 609982
RefSeq - NM_013245
RefSeq Peptide - NP_037377
swissprot - A0A024R705
swissprot - Q9UN37
Ensembl - ENSG00000132612
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps4aENSDARG00000030114Danio rerio
 ENSGALG00000040713Gallus gallus
 Vps4aENSMUSG00000031913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC026464.4ENSG0000026091491
VPS4B / O75351 / vacuolar protein sorting 4 homolog BENSG0000011954181
Q9BW62 / KATNAL1 / katanin catalytic subunit A1 like 1ENSG0000010278138
KATNA1 / O75449 / katanin catalytic subunit A1ENSG0000018662537
Q8IYT4 / KATNAL2 / katanin catalytic subunit A1 like 2ENSG0000016721633


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000916 actomyosin contractile ring contraction TAS
 biological_processGO:0000920 cell separation after cytokinesis IMP
 biological_processGO:0006622 protein targeting to lysosome IMP
 biological_processGO:0006900 vesicle budding from membrane IMP
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0006998 nuclear envelope organization TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0009838 abscission IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0016236 macroautophagy NAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0019076 viral release from host cell IMP
 biological_processGO:0031468 nuclear envelope reassembly TAS
 biological_processGO:0032367 intracellular cholesterol transport IMP
 biological_processGO:0032466 negative regulation of cytokinesis IMP
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0034058 endosomal vesicle fusion IMP
 biological_processGO:0036258 multivesicular body assembly NAS
 biological_processGO:0039702 viral budding via host ESCRT complex IGI
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0044878 mitotic cytokinesis checkpoint IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061640 cytoskeleton-dependent cytokinesis TAS
 biological_processGO:0061738 late endosomal microautophagy ISS
 biological_processGO:0072319 vesicle uncoating IMP
 biological_processGO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:1902188 positive regulation of viral release from host cell IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903774 positive regulation of viral budding via host ESCRT complex IMP
 biological_processGO:1903902 positive regulation of viral life cycle IMP
 biological_processGO:1904896 ESCRT complex disassembly NAS
 biological_processGO:1904903 ESCRT III complex disassembly NAS
 cellular_componentGO:0000815 ESCRT III complex IDA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005774 vacuolar membrane IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody TAS
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0090543 Flemming body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity NAS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042623 ATPase activity, coupled NAS


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086065 CHMP5 / Q9NZZ3 / charged multivesicular body protein 5  / complex
 ENSG00000009844 VTA1 / Q9NP79 / vesicle trafficking 1  / complex
 ENSG00000119541 VPS4B / O75351 / vacuolar protein sorting 4 homolog B  / complex






 

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