ENSG00000119541


Homo sapiens

Features
Gene ID: ENSG00000119541
  
Biological name :VPS4B
  
Synonyms : O75351 / vacuolar protein sorting 4 homolog B / VPS4B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.33
Gene start: 63389190
Gene end: 63422483
  
Corresponding Affymetrix probe sets: 218171_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465944
Ensembl peptide - ENSP00000238497
Ensembl peptide - ENSP00000465846
NCBI entrez gene - 9525     See in Manteia.
OMIM - 609983
RefSeq - XM_011526268
RefSeq - NM_004869
RefSeq - XM_006722582
RefSeq Peptide - NP_004860
swissprot - A0A024R2C5
swissprot - O75351
swissprot - K7EKZ3
swissprot - K7EL71
Ensembl - ENSG00000119541
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-185p13.1ENSDARG00000095837Danio rerio
 VPS4BENSGALG00000012879Gallus gallus
 Vps4bENSMUSG00000009907Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VPS4A / Q9UN37 / vacuolar protein sorting 4 homolog AENSG0000013261280
AC026464.4ENSG0000026091474
Q9BW62 / KATNAL1 / katanin catalytic subunit A1 like 1ENSG0000010278136
KATNA1 / O75449 / katanin catalytic subunit A1ENSG0000018662536
Q8IYT4 / KATNAL2 / katanin catalytic subunit A1 like 2ENSG0000016721633


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036181  MIT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000920 cell separation after cytokinesis IMP
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport IDA
 biological_processGO:0016236 macroautophagy NAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0019076 viral release from host cell IMP
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0032510 endosome to lysosome transport via multivesicular body sorting pathway IMP
 biological_processGO:0033993 response to lipid IDA
 biological_processGO:0036258 multivesicular body assembly NAS
 biological_processGO:0039702 viral budding via host ESCRT complex IGI
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0050792 regulation of viral process IMP
 biological_processGO:0051261 protein depolymerization IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0061738 late endosomal microautophagy IEA
 biological_processGO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 biological_processGO:1902188 positive regulation of viral release from host cell IMP
 biological_processGO:1903542 negative regulation of exosomal secretion IMP
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903724 positive regulation of centriole elongation IMP
 biological_processGO:1903902 positive regulation of viral life cycle IMP
 biological_processGO:1904903 ESCRT III complex disassembly NAS
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0090543 Flemming body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0042623 ATPase activity, coupled NAS
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086065 CHMP5 / Q9NZZ3 / charged multivesicular body protein 5  / complex
 ENSG00000009844 VTA1 / Q9NP79 / vesicle trafficking 1  / complex
 ENSG00000132612 VPS4A / Q9UN37 / vacuolar protein sorting 4 homolog A  / complex






 

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